{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:25:24Z","timestamp":1787801124258,"version":"build-2784847793"},"reference-count":62,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This systematic review and meta\u2010analysis evaluated the risk factors for bronchopulmonary dysplasia associated pulmonary hypertension (BPD\u2010PH) in extremely premature infants (gestational age\u2009&lt;\u200932 weeks) and its impact on outcomes. A computerized search of eight databases was performed, from the time of library construction to February 2024. The quality of the included studies was assessed with the Newcastle\u2012Ottawa scale. Statistical analyses were performed using RevMan 5.4.1 and Stata 16.0 software. Meta\u2010analysis of 2137 extremely premature infants revealed that oligohydramnios (OR\u2009=\u20092.21, 95% CI 1.06\u20134.61), low gestational age (SMD\u2009=\u2009\u22120.36, 95% CI \u22120.47 to \u22120.24), low birth weight (SMD\u2009=\u2009\u22120.54, 95% CI \u22120.74 to \u22120.35), small for gestational age (OR\u2009=\u20091.61, 95% CI 1.06\u20132.44), neonatal respiratory distress syndrome (OR\u2009=\u20092.05, 95% CI 1.45\u20132.91), grade\u00a0III bronchopulmonary dysplasia (OR\u2009=\u20094.67, 95% CI 1.34\u201316.30), and sepsis (OR\u2009=\u20092.25, 95% CI 1.69\u20134.66) were risk factors for BPD\u2010PH, whereas antenatal steroids (OR\u2009=\u20090.66, 95% CI 0.49\u20130.88) were protective factors. BPD\u2010PH led to the extension of oxygen therapy (SMD\u2009=\u20090.67, 95% CI 0.42\u20130.92) and hospital stay (SMD\u2009=\u20090.77, 95% CI 0.14\u20131.40), and elevated the risk of discharged on oxygen (OR\u2009=\u20092.77, 95% CI 1.35\u20135.70) and death (OR\u2009=\u20094.38, 95% CI 2.21\u20138.69). BPD\u2010PH is a multifactorial disease. In this study, a total of\u00a0seven risk factors, and one protective factor for BPD\u2010PH were identified in extremely premature infants. By managing and mitigating these factors, it is possible to decrease the occurrence of BPD\u2010PH. Furthermore, BPD\u2010PH may increase the risk of a poor prognosis in extremely premature infants.<\/jats:p>","DOI":"10.1002\/ppul.27220","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T08:48:32Z","timestamp":1724402912000},"page":"3117-3129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk factors and clinical outcomes of pulmonary hypertension associated with bronchopulmonary dysplasia in extremely premature infants: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3139-9044","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neonatology General Hospital of Northern Theater Command Shenyang China"},{"name":"Post\u2010graduate College China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Shuang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Neonatology General Hospital of Northern Theater Command Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neonatology General Hospital of Northern Theater Command Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonatology General Hospital of Northern Theater Command Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neonatology General Hospital of Northern Theater Command Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-6694","authenticated-orcid":false,"given":"Bing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neonatology General Hospital of Northern Theater Command Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.09.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.11.1099"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-022-01179-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0303-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-021-03766-w"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.028"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03337-2020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2010.40.3.131"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1827"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201409-1594OC"},{"issue":"11","key":"e_1_2_9_12_1","first-page":"893","article-title":"[Clinical features and prognosis of bronchopulmonary dysplasia complicated by pulmonary hypertension in preterm infants]","volume":"20","author":"Wang CH","year":"2018","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894019878598"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/09622802231172043"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1429"},{"issue":"9","key":"e_1_2_9_21_1","first-page":"747","article-title":"[Risk factors and prognosis of bronchopulmonary dysplasia associated pulmonary hypertension in preterm infants]","volume":"58","author":"Chen C","year":"2020","journal-title":"Zhonghua er ke za zhi = Chinese journal of pediatrics"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327891"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24211"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198510000-00023"},{"issue":"8","key":"e_1_2_9_25_1","article-title":"Signaling pathways involved in the development of bronchopulmonary dysplasia and pulmonary hypertension","volume":"7","author":"Mathew R","year":"2020","journal-title":"Children (Basel, Switzerland)"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-8932.94818"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20257"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(03)00076-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211673"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.02.034"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90210-4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051539"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-017-2403-z"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.08.046"},{"issue":"4","key":"e_1_2_9_35_1","article-title":"Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth","volume":"8","author":"Brownfoot FC","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01535-5"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2019.05.002"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200109000-00024"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000259226.62431.78"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-017-0443-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20205"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181c13276"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2006.12.005"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2015.03.007"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-1209"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.45299"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01846.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0249"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12444"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2101140"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51617-8"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318160f03b"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00560.2017"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030548"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.108"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0971"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.75"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.07.035"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.043"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201812-2348OC"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02590-6"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.648972"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.27220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:18:48Z","timestamp":1771240728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ppul.27220"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27220","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"2024-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}