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Despite their use, limited data exist to demonstrate a clinically significant impact of PPIs on key endpoints in pwCF. Furthermore, the advent of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy may modify the need for use. These notions, coupled with the potential for adverse outcomes associated with long\u2010term PPI use in pwCF, should facilitate re\u2010evaluation of long\u2010term PPI use in pwCF and promote potential deprescribing. Despite limited data on PPI deprescribing in pwCF, it intuitively mirrors the existing guidance in adults in the general population, but with added consideration given to tapering strategy, and monitoring for CF\u2010specific outcomes such as nutritional and respiratory status. The development of a monitoring and re\u2010initiation plan is key to reducing deprescribing inertia. 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