{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:57:39Z","timestamp":1789761459987,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of different vasodilators in the treatment of persistent pulmonary hypertension of the newborn (PPHN) by a Bayesian network meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched databases (Cochrane, PubMed, Embase, and Web of Science) from January, 1990 up to December, 2023. Randomized controlled trials on the use of vasodilators in the treatment of PPHN. We extracted details of population, intervention, and outcome indicators. R and STATA software were used for data analysis. Sixteen articles were included, encompassing 776 neonates with PPHN. Among them, 12\u00a0articles were included in the quantitative analysis. The vasodilators included Sildenafil, Bosentan, Milrinone, Magnesium, Adenosine, and Tadalafil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Bayesian network meta\u2010analysis results suggested that compared to placebo, Milrinone [OR\u2009=\u20090.125, 95% CI (0.0261, 0.562)], Sildenafil [OR\u2009=\u20090.144, 95% CI (0.0428, 0.420)], and Sildenafil_Milrinone [OR\u2009=\u20090.0575, 95% CI (0.00736, 0.364)] reduced the mortality, but the difference among the three was not significant. There was also no significant difference in the incidence of hypotension, the duration of mechanical ventilation, and the use of extracorporeal membrane oxygenation\u00a0among the vasodilators. Compared to Bosentan, Adenosine was more effective in reducing the oxygenation index [MD\u2009=\u2009\u221212.78, 95% CI (\u221225.56, \u22120.03)], and Magnesium was less effective in reducing the oxygenation index than Sildenafil [MD\u2009=\u20095.19, 95% CI (1.23, 9.2)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Milrinone, Sildenafil, and Sildenafil_Milrinone reduced the mortality of neonates with PPHN. More clinical trials are needed to verify the efficacy and safety of vasodilators in the treatment of PPHN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27234","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:58:20Z","timestamp":1724828300000},"page":"3467-3482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vasodilators for persistent pulmonary hypertension of the newborn: A network meta\u2010analysis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-1649","authenticated-orcid":false,"given":"Keren","family":"Luo","sequence":"first","affiliation":[{"name":"Sichuan University\/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Department of Neonatology West China Second Hospital, Ministry of Education Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Sichuan University\/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Department of Neonatology West China Second Hospital, Ministry of Education Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongju","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan University\/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Department of Neonatology West China Second Hospital, Ministry of Education Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University Chengdu City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University Chengdu City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.14"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2011.12.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308591"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1450"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25444"},{"issue":"3","key":"e_1_2_11_9_1","first-page":"319","article-title":"Efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn: a metaanalysis","volume":"24","author":"Li LX","year":"2022","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_11_10_1","volume-title":"International prospective register of systematic reviews","author":"PROSPERO"},{"key":"e_1_2_11_11_1","unstructured":"HigginsJPT SJ MJP. 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