{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:07:34Z","timestamp":1771243654991,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010779","name":"Centre hospitalier universitaire Sainte-Justine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      In children with acute respiratory distress syndrome receiving mechanical ventilation, the peak inspiratory pressure (PIP) is close to plateau pressure (P\n                      <jats:sub>PLAT<\/jats:sub>\n                      ) when inspiratory flow approaches zero. We aimed to evaluate the reliability of PIP to estimate P\n                      <jats:sub>PLAT<\/jats:sub>\n                      in infants with severe respiratory viral infection (SRVI), characterized by increased airway resistance, and the accuracy of an equational model to estimates P\n                      <jats:sub>PLAT<\/jats:sub>\n                      (eP\n                      <jats:sub>PLAT<\/jats:sub>\n                      ) based on PIP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective observational study including mechanically ventilated children (1 to 24 month old) with SRVI, whose respiratory mechanics measurements were performed to evaluate PIP and P\n                      <jats:sub>PLAT.<\/jats:sub>\n                      The measured P\n                      <jats:sub>PLAT<\/jats:sub>\n                      was compared with the result of the equation: eP\n                      <jats:sub>PLAT<\/jats:sub>\n                      \u2009=\u2009PIP \u2013 [5.067 \u2013 (0.858\u2009\u00d7\u2009static compliance) \u2013 (0.018\u2009\u00d7\u2009inspiratory resistance) \u2013 (0.390\u2009\u00d7\u2009pressure above positive\u2010end expiratory pressure) + (4.989\u2009\u00d7\u2009inspiratory time)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven patients were included, with a median age of 3 (2\u20135) months. They presented a high inspiratory and expiratory resistance (136\u2009\u00b1\u200943 and 168\u2009\u00b1\u200966 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O\/L\/s, respectively) and a moderate reduction in static compliance: 0.75\u2009\u00b1\u20090.3\u2009mL\/kg\/cmH\n                      <jats:sub>2<\/jats:sub>\n                      O. PIP overestimated P\n                      <jats:sub>PLAT<\/jats:sub>\n                      (33\u2009\u00b1\u20093 and 26\u2009\u00b1\u20095 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), with a mean difference of 7.3\u2009\u00b1\u20094 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O. Moreover, the Bland\u2010Altman analysis demonstrated a mean difference between P\n                      <jats:sub>PLAT<\/jats:sub>\n                      and eP\n                      <jats:sub>PLAT<\/jats:sub>\n                      of 1.0\u2009\u00b1\u20094.0 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, with 95% limits of agreement of \u20136.9 and 8.8.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A significant difference between PIP and P\n                      <jats:sub>PLAT<\/jats:sub>\n                      was observed in infants with SRVI. The equation model was inaccurate for estimating P\n                      <jats:sub>PLAT<\/jats:sub>\n                      based on PIP. Any estimation of P\n                      <jats:sub>PLAT<\/jats:sub>\n                      from PIP needs to consider the resistance component of the respiratory system.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27245","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T09:01:45Z","timestamp":1726736505000},"page":"3518-3523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peak inspiratory pressure lacks accuracy to estimate plateau pressure in infants with severe obstructive lower airway disease"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0534-3972","authenticated-orcid":false,"given":"Cec\u00edlia R.","family":"Buratti","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Intensive Care, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Graduate Program in Child and Adolescent Health Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-0198","authenticated-orcid":false,"given":"Cinara","family":"Andreolio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Intensive Care, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Graduate Program in Child and Adolescent Health Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-8884","authenticated-orcid":false,"given":"Francisco","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Intensive Care, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Graduate Program in Child and Adolescent Health Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia B.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Graduate Program in Child and Adolescent Health Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica","family":"Marcon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Intensive Care, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia F.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Intensive Care, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Graduate Program in Child and Adolescent Health Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jefferson P.","family":"Piva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Intensive Care, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Graduate Program in Child and Adolescent Health Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Jouvet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sainte\u2010Justine Hospital, Pediatric Intensive Care Montreal Quebec 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