{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:55:36Z","timestamp":1786967736306,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>There is growing understanding that Social Determinants of Health (SDH) impact on the outcomes of different pediatric conditions. We aimed to determine whether SDH affect the severity of MIS\u2010C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Retrospective cohort study, 2021\u20132023. Children and adolescents with MIS\u2010C younger than 18 years of age fulfilling the MIS\u2010C CDC definition within the REKAMLATINA network were invited to participate. We assessed the\n                      <jats:bold>i<\/jats:bold>\n                      mpact of SDH on the risk of children with MIS\u2010C to be diagnosed with shock, need of inotropes, respiratory support, transfusion, and death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and seventy seven patients from 30 centers in 13 countries were included. Of them, 241 children from the four most\u2010represented countries were included in the final analysis. Food insecurity, higher distance from a health center, not possessing a private vehicle to transport the patient to hospital, and having a home in poor condition, were associated with low LVEF, need of transfusion, shock, and need for respiratory support, when controlling for age, BMI, and ethnicity. The Score of Social Disadvantage was associated with Shock (OR: 1.35, P: 0.011, 95% CI: 1.07\u20131.71), Respiratory support (OR: 1.39, P: 0.005, 95% CI: 1.1\u20131.75), Transfusion (OR: 1.63, P0.013, 95% CI 1.1\u20132.41), but not death (OR: 0.76, P: 0.38, 95% CI: 0.41\u20131.40).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among a large cohort of Latin American children with MIS\u2010C, SDH negatively affect outcomes. These findings reinforce the need for better investigation of the role of SDH in MIS\u2010C and other inflammatory conditions and may guide public health interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27313","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T06:29:43Z","timestamp":1735194583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of social determinants of health on the outcomes of Latin American children with Multisystem Inflammatory Syndrome (MIS\u2010C)"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-2639","authenticated-orcid":false,"given":"Danilo","family":"Buonsenso","sequence":"first","affiliation":[{"name":"Area Pediatrica, Dipartimento di Scienze della Vita e Sanit\u00e0 Pubblica Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"},{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario A. Gemelli Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1160-1456","authenticated-orcid":false,"given":"Anna","family":"Camporesi","sequence":"additional","affiliation":[{"name":"Pediatric Anesthesia and Intensive Care, Vittore Buzzi Children's Hospital Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sawaya","sequence":"additional","affiliation":[{"name":"University California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9157-9227","authenticated-orcid":false,"given":"Rolando","family":"Ulloa\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Hospital Nacional de Ni\u00f1os \u201cDr. Carlos S\u00e1enz Herrera\u201d, Caja Costarricense de Seguro Social (CCSS) San Jos\u00e9 Costa Rica"},{"name":"Universidad de Ciencias M\u00e9dicas (UCIMED) e Instituto de Investigaci\u00f3n en Ciencias M\u00e9dicas (IICIMED) San Jos\u00e9 Costa Rica"},{"name":"Academia Nacional de Medicina de Costa Rica (ACANAMED) San Jos\u00e9 Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-1296","authenticated-orcid":false,"given":"Enrique","family":"Faugier\u2010Fuentes","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda Hospital Infantil de M\u00e9xico Federico G\u00f3mez Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Due\u00f1as","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda Hospital Nacional de Ni\u00f1os Benjam\u00edn Bloom San Salvador El Salvador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando A.","family":"Paternina\u2010de la Ossa","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda Universidad 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