{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:01:10Z","timestamp":1787238070575,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A significant percentage of patients with asthma appear to benefit from the addition of long\u2010acting \u03b22\u2010agonists (LABAs) to ICS to achieve better control of their disease. The aim of the present study was to determine the cost\u2010utility of single inhaler combination inhaled ICS\/LABAs as both maintenance and reliever (SMART) versus remaining at the same treatment step with fixed\u2010dose ICS\u2013LABA maintenance with a short\u2010acting \u03b22\u2010agonist (SABA) as reliever in patients aged 12 years or more with uncontrolled asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Markov\u2010type model was developed to estimate the costs and health outcomes of a simulated cohort of patients aged 12 years or more with uncontrolled asthma treated for 12 months. The effectiveness data and transition probabilities were obtained from a recent meta\u2010analysis. Cost data were obtained from official databases provided by the Colombian Ministry of Health. The main outcome was the variable \u201cquality\u2010adjusted life\u2010years\u201d (QALYs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The base\u2010case analysis showed that compared with remaining at the same GINA treatment step with ICS\/LABA maintenance plus SABA reliever, ICS\/LABAs as SMART was associated with lower costs, US$2,906.92 versus $4,462.02 average cost per patient, and the greatest gain in QALYs, 0.8540 versus 0.8258 QALYs on average per patient, thus leading to dominance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with remaining at the same GINA treatment step with ICS\/LABA maintenance plus SABA reliever, ICS\/LABAs as SMART is more cost\u2010effective in patients aged 12 years or more with uncontrolled asthma. This is because ICS\/LABAs as SMART showed a greater gain in QALYs at lower total treatment costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27328","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:34:57Z","timestamp":1729676097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A cost\u2010utility analysis of single maintenance and reliever (SMART) therapy as compared to step 3 fixed\u2010dose therapy in patients aged 12 years or more with uncontrolled asthma"],"prefix":"10.1002","volume":"60","author":[{"given":"Carlos E.","family":"Rodr\u00edguez\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine Universidad Nacional de Colombia Bogota Colombia"},{"name":"Department of Pediatric Pulmonology, School of Medicine Universidad El Bosque Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica P.","family":"Sossa\u2010Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Universidad Nacional de Colombia Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4281","authenticated-orcid":false,"given":"Jose A.","family":"Castro\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, School of Medicine Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-12-17"},{"key":"e_1_2_9_3_1","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2024. Updated May 2024. Available from:www.ginasthma.org(Accessed June 17th 2024)."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00283202"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.2769"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2021.2019266"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.0615"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199813040-00003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25541"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.05.023"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-060ST"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198526629.001.0001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.10.011"},{"key":"e_1_2_9_16_1","unstructured":"Sistema de Informacion de precios de medicamentos\u2014SISMED. Listado de precios promedio y unidades en la cadena de comercializacion de medicamentos. Ministerio de la Proteccion Social. Republica de Colombia;2022.https:\/\/www.sispro.gov.co\/central-prestadores-de-servicios\/Pages\/SISMED-Sistema-de-Informacion-de-Precios-de-Medicamentos.aspx. Accessed March 5th 2024."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.06.015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-018-0205-4"},{"key":"e_1_2_9_19_1","unstructured":"Gu\u0131a de Practica Clinica (GPC) para el diagnostico atencion integral y seguimiento de ninos y ninas con diagnostico de asma: Available athttps:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/INEC\/IETS\/GPC_Comp_Asma.pdf. Accessed March 5th 2024."},{"key":"e_1_2_9_20_1","volume-title":"The Delphi method. Techniques andapplications","author":"Linstone H","year":"2002"},{"key":"e_1_2_9_21_1","unstructured":"Banco de la Republica. Colombia. 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