{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:09:24Z","timestamp":1771430964932,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The diagnosis of cystic fibrosis (CF) can impact the mental health of caregivers. This study aimed to explore prevalence of postpartum depression (PPD) symptoms in caregivers of infants with CF or CFTR\u2010related metabolic syndrome (CRMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, observational study was conducted in a CF clinic at a tertiary hospital over 4 years. Caregivers of infants with CF\/CRMS completed serial surveys over the first year of life. Surveys included the Edinburgh Postnatal Depression Scale (EPDS), Patient Health Questionnaire\u20109 (PHQ\u20109) and the General Anxiety Disorder\u20107 (GAD\u20107). A control group of healthy infant caregivers was used for comparative analysis of EPDS scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analyses were conducted on 55 caregivers of 42 infants with CF\/CRMS and 915 caregivers of healthy infants. Caregivers of infants with CF\/CRMS had a significantly higher prevalence of elevated EPDS scores and higher mean EPDS scores for visit 1 (age 1\u20132mo) and visit 3 (age 6\u20139mo) compared to healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both). There was a higher prevalence of caregivers identifying thoughts of self\u2010harm in the CF\/CRMS cohort (8.3%) compared to caregivers of healthy controls (1.2%) at visit 1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and at visit 3 (CF\/CRMS 8.8%; control 1.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). EPDS scores correlated with PHQ\u20109 and GAD\u20107 scores, particularly earlier in the infant's life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Caregivers of infants with CF\/CRMS may be at higher risk of PPD and thoughts of self\u2010harm when compared to healthy controls. Given what is known about the impact of PPD on mental and physical health of children, early identification is vital for this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27364","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T07:11:00Z","timestamp":1730185860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Edinburgh postnatal depression scale score elevation in caregivers of infants with cystic fibrosis"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-5443","authenticated-orcid":false,"given":"Michelle L.","family":"Gillespie","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine The Ohio State University Columbus OH USA"},{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus OH USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Jayaram","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus OH USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah","family":"Eisner","sequence":"additional","affiliation":[{"name":"Biostatistics Resource Nationwide Children's Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Sliemers","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-4107","authenticated-orcid":false,"given":"Kimberly","family":"Pasley","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-0905","authenticated-orcid":false,"given":"Karen","family":"McCoy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus OH USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-2710","authenticated-orcid":false,"given":"Katelyn","family":"Krivchenia","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus OH USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000244"},{"key":"e_1_2_8_3_1","unstructured":"Cystic Fibrosis Foundation Patient Registry: 2022 Annual Data Report.Bethesda MD:2023Cystic Fibrosis Foundation."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21423"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2020.04.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-022-02307-w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205983"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207488"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25213"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.12.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2023.04.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.11.022"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4363"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.112769"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2008.02.020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.6.782"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883221114984"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000368"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.12.121"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-536X.2003.00242.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2016.10.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3259"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2648.2003.02857.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1985"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09441"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13010154"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.27364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:28:22Z","timestamp":1771428502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ppul.27364"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27364","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"2024-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27364"}}