{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:31:37Z","timestamp":1792114297652,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Risk factors for progression of adenovirus (AdV)\u2010associated bronchiolitis (AdV\u2010B) to post\u2010infectious bronchiolitis obliterans (PIBO) are poorly defined. We aimed to investigate this in a multicenter cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter hospital\u2010based analysis included children admitted with AdV\u2010B in Jerusalem during 2016\u20132022. A case\u2010control analysis included AdV\u2010PIBO patients in Jerusalem during 2005\u20132023. Cases were compared to randomly assigned controls admitted with AdV\u2010B without progression to AdV\u2010PIBO. Multivariate analysis with logistic regression was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The annual incidence of AdV\u2010B admissions and AdV\u2010PIBO increased during 2016\u20132022, during which 1522 children were admitted with AdV\u2010B and 8 developed AdV\u2010PIBO (0.5%). Of 30 AdV\u2010PIBO cases identified during 2005\u20132023, available data were compared for 25 of them (72% boys; mean age \u00b1 standard deviation 1.2\u2009\u00b1\u20090.8 years) and 139 controls (66% boys; mean age 1.0\u2009\u00b1\u20090.6 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.5 for age). Jewish ethnicity was more common in the AdV\u2010PIBO versus control group (92% vs. 66%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), as were oxygen supplementation (84% vs. 45%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), noninvasive ventilation (20% vs. 4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), consolidations on chest X\u2010ray (44% vs. 19%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), and lymphopenia (92% vs. 46%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Combining Jewish ethnicity, lymphopenia, consolidations, and prolonged admission as independent risk factors yielded positive and negative predictive values of 68.8% and 90.5%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings emphasize the urgent need for targeted preventive and management strategies. The identification of Jewish ethnicity as a risk factor may imply a genetic contribution to Adv\u2010PIBO risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27411","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T09:29:43Z","timestamp":1732181383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk Factors for Developing Adenovirus\u2010Associated Post\u2010Infectious Bronchiolitis Obliterans"],"prefix":"10.1002","volume":"60","author":[{"given":"Oren","family":"Gordon","sequence":"first","affiliation":[{"name":"Pediatric Infectious Unit Hadassah Medical Center, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"},{"name":"The Goldyne Savad Institute of Gene Therapy, Hadassah Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadhud","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Hadassah Medical Center, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Guzner","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Cohen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Ben\u2010Meir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla","family":"Samman","sequence":"additional","affiliation":[{"name":"Pediatric Department Hadassah Medical Center, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Sergienko","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana G.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Infectious Diseases Hadassah Medical Organization, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"},{"name":"The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel\u2010Canada, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6796-3459","authenticated-orcid":false,"given":"Elie","family":"Picard","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Shaare Zedek Medical Center, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Kerem","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Hadassah Medical Center, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-2707","authenticated-orcid":false,"given":"Oded","family":"Shamriz","sequence":"additional","affiliation":[{"name":"The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel\u2010Canada, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"},{"name":"Allergy and Clinical Immunology Unit, Department of Medicine Hadassah Medical Organization, Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584923"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21080"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26570"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.722885"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5852827"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.24.1.72"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_374_20"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11111268"},{"key":"e_1_2_10_10_1","first-page":"642","volume-title":"The Harriet Lane Handbook. 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