{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:46:54Z","timestamp":1785246414283,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Wheezing illnesses, especially those triggered by rhinovirus infection, cause a major disease burden, and they often precede asthma. Environmental exposures are known to affect recurrence of wheezing. We investigated the relations of population density, greenness (forested areas), and socioeconomic factors of the living surroundings to the burden of asthma in children with prior bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three hundred and ninety\u2010four children, aged 0\u201324 months, with doctor\u2010diagnosed bronchiolitis were enrolled in the MARC\u201030 Finland study. We assessed the children's early\u2010life exposures to greenness and socioeconomic factors using time\u2010series of Corine Land Cover data and Statistics Finland's grid data. We compared the living surroundings data to the prescription drug purchases and special asthma reimbursement benefits until the age 8 years; asthma data were from the Social Insurance Institution of Finland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children living in sparsely populated areas had lighter asthma disease burden than children living in densely populated ones, with burden measured in median bronchodilator (50DDD [defined daily dose] vs. 104DDD,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and inhaled corticosteroid (0DDD vs. 123DDD,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) purchases. In the subgroup of children with rhinovirus\u2010induced bronchiolitis, children living in more forested areas developed asthma 10 months later than those with less forested areas (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Neighborhood socioeconomic characteristics were not associated with differences in asthma burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sparsely populated areas and forested environments seem to have a beneficial association with children's respiratory health. These findings warrant further studies on the protective health effects of greenness and the type of biodiversity around homes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27436","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T09:04:48Z","timestamp":1733389488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Residential Area Characteristics Are Associated With Asthma Burden in Children"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-0856","authenticated-orcid":false,"given":"Riku","family":"Erkkola","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Turku University Hospital University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonzales\u2010Inca","sequence":"additional","affiliation":[{"name":"Department of Geography and Geology University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Vahtera","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Bergroth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital Nova of Central Finland, Wellbeing Services County of Central Finland Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8858-1134","authenticated-orcid":false,"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Medical Technology, Centre for Child Health Research University of Tampere Tampere Finland"},{"name":"Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Jartti","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Turku University Hospital University of Turku Turku Finland"},{"name":"Research Center of Clinical Medicine University of Oulu Oulu Finland"},{"name":"Department of Pediatrics and Adolescent Medicine Oulu University Hospital Oulu Finland"},{"name":"Research Unit of Clinical Medicine University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052632"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.06.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007302"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.026"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.03.032"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052412"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13741"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.08.035"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12545"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12915"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scs.2023.104566"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.032"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.04.049"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-018-0151-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109914"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108953"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1509ST"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.08.007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-018-0149-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13763"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2223"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.08.043"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00066-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba2578"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2023.1152927"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00084"},{"key":"e_1_2_9_31_1","unstructured":"\u201cThe 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