{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:17Z","timestamp":1786978337163,"version":"build-2736575974"},"reference-count":4,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Following the approval of elexacaftor\/tezacaftor\/ivacaftor (ETI), there have been post\u2010marketing reports and published cases of papilledema and intracranial hypertension in children with cystic fibrosis (CF) taking ETI. In those reports, the patients often presented with marked symptoms and concomitant hypervitaminosis A. In this multicenter case series, we report eight cases of papilledema in children with CF taking ETI that were diagnosed via routine eye exam, the majority of whom presented with minimal to no symptoms and all had normal serum Vitamin A levels.<\/jats:p>","DOI":"10.1002\/ppul.27455","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:55:46Z","timestamp":1734670546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Papilledema in Children With Cystic Fibrosis Receiving Elexacaftor\/Tezacaftor\/Ivacaftor: A Multicenter Case Series"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-2613","authenticated-orcid":false,"given":"Charissa W.","family":"Kam","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of North Carolina Medical Center Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-5628","authenticated-orcid":false,"given":"Cameron J.","family":"McKinzie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of North Carolina Medical Center Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-7249","authenticated-orcid":false,"given":"Nicole E.","family":"Omecene","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science Virginia Commonwealth University School of Pharmacy Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Peters","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Allied Health Professions South Dakota State University Brookings South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-0481","authenticated-orcid":false,"given":"Rebecca S.","family":"Pettit","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Riley Hospital for Children, Indiana University Health Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret O.","family":"Poisson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Georgia Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Driscoll Children's Hospital Corpus Christi Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2021.04.018"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0380LE"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.01.010"},{"key":"e_1_2_5_5_1","unstructured":"FDA Adverse Events Reporting System (FAERS) Public Dashboard\u2014FDA Adverse Events Reporting System (FAERS) Public Dashboard | Sheet\u2014Qlik Sense. (n.d.). Retrieved May 2 2024 fromhttps:\/\/fis.fda.gov\/sense\/app\/95239e26-e0be-42d9-a960-9a5f7f1c25ee\/sheet\/45beeb74-30ab-46be-8267-5756582633b4\/state\/analysis."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.27455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:31:35Z","timestamp":1771428695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ppul.27455"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27455","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"2024-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27455"}}