{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:08:11Z","timestamp":1791526091911,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Since 2019 as\u2010needed low\u2010dose ICS\u2010formoterol in a single inhaler has been recommended for treatment of mild asthma in children aged more than 12 years. Alternatively, the use of ICS\u2010albuterol has been proposed in countries where ICS\u2010formoterol is not available or affordable. The aim of the present study was to evaluate the cost\u2010utility of as\u2010needed ICS\u2010albuterol in separate inhalers compared to ICS\u2010formoterol in a single inhaler as reliever therapy in pediatric patients with mild asthma living in Colombia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Markov\u2010type model was developed to estimate the costs and health outcomes of a simulated cohort of pediatric patients with mild asthma treated for 12 months. The effectiveness data and transition probabilities were obtained from relevant randomized clinical trials (RCTs). Cost data were obtained from official databases provided by the Colombian Ministry of Health. The main outcome was the variable \u201cquality\u2010adjusted life\u2010years\u201d (QALYs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The base\u2010case analysis showed that compared with the use of as\u2010needed ICS\u2010albuterol in separate inhalers, the use of ICS\u2010formoterol in a single in pediatric patients with mild asthma was associated with lower costs (US$475.51 vs. 735.33 average cost per patient) and the greatest gain in QALYs (0.9367 vs. 0.9352 QALYs on average per patient), thus leading to dominance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with the use of as\u2010needed ICS\u2010albuterol in separate inhalers, the use of ICS\u2010formoterol in a single inhaler as reliever therapy is cost\u2010effective in patients aged 12 years or more with mild asthma, because it showed a greater gain in QALYs at lower total treatment costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27466","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T04:01:01Z","timestamp":1735617661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["As\u2010Needed Inhaled Corticosteroid\u2010Formoterol in a Single Inhaler Compared to Inhaled Corticosteroid\u2010Albuterol in Separate Inhalers as Reliever Therapy in Mild Pediatric Asthma: A Cost\u2010Utility Analysis"],"prefix":"10.1002","volume":"60","author":[{"given":"Carlos E.","family":"Rodr\u00edguez\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine, Universidad Nacional de Colombia Bogota Colombia"},{"name":"Department of Pediatric Pulmonology School of Medicine, Universidad El Bosque Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica P.","family":"Sossa\u2010Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine, Universidad Nacional de Colombia Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-6612","authenticated-orcid":false,"given":"Jefferson Antonio","family":"Buendia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology School of Medicine, Research Group in Pharmacology and Toxicology (INFARTO), Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization. Asthma https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/asthma accessed November 21 2024."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-016-0029-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01394.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2021.2008430"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2012.06.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.01.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199813040-00003"},{"key":"e_1_2_9_9_1","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2024. Updated May 2024 www.ginasthma.org (accessed November 21 2024)."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202011-1386OC"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62145-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.06.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23073"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198526629.001.0001"},{"key":"e_1_2_9_15_1","unstructured":"Gu\u0131a de Practica Clinica (GPC) para el diagnostico atencion integral y seguimiento de ninos y ninas con diagnostico de asma https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/INEC\/IETS\/GPC_Comp_Asma.pdf accessed November 21 2024."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzh086"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.767909"},{"key":"e_1_2_9_18_1","unstructured":"Sistema de Informacion de precios de medicamentos\u2014SISMED. Listado de precios promedio y unidades en la cadena de comercializacion de medicamentos. Ministerio de la Proteccion Social. Republica de Colombia; 2022 https:\/\/www.sispro.gov.co\/central-prestadores-de-servicios\/Pages\/SISMED-Sistema-de-Informacion-de-Precios-de-Medicamentos.aspx accessed November 21 2024."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.06.015"},{"key":"e_1_2_9_20_1","volume-title":"The Delphi Method. Techniques and Applications","author":"Linstone H.","year":"2002"},{"key":"e_1_2_9_21_1","unstructured":"Banco de la Republica. Colombia https:\/\/www.banrep.gov.co\/es accessed November 21 2024."},{"key":"e_1_2_9_22_1","unstructured":"Banco de la Republica Colombia. Series estad\u0131sticas. Tasas de cambio. 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