{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:23:23Z","timestamp":1794363803812,"version":"4.9.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A main feature of CDH is lung hypoplasia and the related presentation of pulmonary hypertension and cardiac dysfunction. Multiple factors influence pulmonary status after CDH: degree of hypoplasia, ventilator\u2010induced injury, altered growth and development of pulmonary structures, reduced diaphragm function and chest wall abnormalities. The evolution of pulmonary sequela in this population is still unclear. We aimed to describe the pulmonary status of our population of CDH\u2010survivors and evaluated on risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CDH\u2010survivors (1998\u22122015) were included and performed lung function tests and chest X\u2010rays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010one (51\/71, 71.8%) participated. Median age was 12.2 (5.5\u201321.4) years, 28 (54.9%) male, 42 (82.4%) had left\u2010sided hernias, 10 (19.6%) needed patch\u2010repair and median length of stay in hospital was 28.0 (IQR 18.5\u201361.6) days in Table 1. Spirometry including bronchodilator response (BDR)\u2010test, body plethysmography, and diffusion capacity, were available for 48, 42, and 40 participants. The mean (SD)\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score for FEV1 and FVC was \u22120.26 (1.70) and \u22120.28 (1.70). Twenty\u2010one (43.8%) had obstructive patterns and six had positive BDR. TLC mean (SD)\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score was \u22120.18 (1.10). Four showed restricted\/mixed patterns and 13 showed signs of hyperinflation. Increased RV\/TLC\u2010ratio and reduced FEV1 was associated with longer time on mechanical ventilation. Diffusion capacity was decreased in three cases. Chest X\u2010ray revealed hernia recurrence (13.9%) and scoliosis (38.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mild obstructive impairment and hyperinflation was frequent in our CDH cohort and only a small subset of restrictive disorders were identified. We advocate follow\u2010up by a specialized multidisciplinary team through childhood and into adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27468","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T02:10:57Z","timestamp":1738116657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary Morbidity in Congenital Diaphragmatic Hernia Survivors Treated at a Non\u2010ECMO Center From 1998 to 2015: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-2907","authenticated-orcid":false,"given":"Ulla Lei","family":"Larsen","sequence":"first","affiliation":[{"name":"Research Unit for Department of Anaesthesiology &amp; Intensive Care Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research Faculty of Health sciences, University of Southern Denmark Odense Denmark"},{"name":"OPEN, Odense Patient Data Explorative Network Odense University Hospital and Institute of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Agertoft","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital of Southern Denmark Aabenraa Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Maria","family":"Herskind","sequence":"additional","affiliation":[{"name":"H.C. Andersen Children's Hospital Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Str\u00f8m","sequence":"additional","affiliation":[{"name":"Research Unit for Department of Anaesthesiology &amp; Intensive Care Odense University Hospital Odense Denmark"},{"name":"Department of Anaesthesia and Critical Care Medicine Hospital S\u00f8nderjylland University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle","family":"Toft","sequence":"additional","affiliation":[{"name":"Research Unit for Department of Anaesthesiology &amp; Intensive Care Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research Faculty of Health sciences, University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Halken","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Faculty of Health sciences, University of Southern Denmark Odense Denmark"},{"name":"H.C. Andersen Children's Hospital Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65000-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.04.015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.2.289"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.20031"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20193"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2022.03.020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20579"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02586-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1557-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24375"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02072-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003E0016-2016"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00016-2016"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00289-2020"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00010-2017"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045728"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22557"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26030645"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23325"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10395-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.3.338"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.09.072"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04278-9"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90152-9"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.005"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.27468","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:29:52Z","timestamp":1771428592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ppul.27468"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27468","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27468"}}