{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:14:21Z","timestamp":1781651661292,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although studies have examined changes in C\u2010reactive protein (CRP) during pulmonary exacerbations (PEX) in people with cystic fibrosis (PwCF), few have evaluated CRP profiles across age groups. Here, we characterize age\u2010related CRP responses to PEX treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured CRP concentrations at the beginning and end of intravenous (IV) antibiotic therapy for PEX in 100 pediatric and 147 adult PwCF at 10 US CF Centers. We examined relationships between CRP and age, lung function, severity of PEX symptoms, and time to next PEX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRP measured at initiation of IV antibiotic treatment for PEX was higher in adults than children, median 8\u2009mg\/L (IQR 4, 32) versus 5\u2009mg\/L (IQR 2, 10), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was a significant correlation between the initial CRP and drop in lung from baseline to the beginning of IV antibiotics in adults and children. Adjusted CRP dropped in response to PEX treatment more commonly in adults than in children (70% vs. 48%, respectively). The range of treatment responses was greater in adults, in those with higher symptom scores, and in those with more advanced lung disease. In adults elevated CRP at the end of treatment was also associated with incomplete recovery of lung function. CRP at the start of IV antibiotics was inversely related to time until the next PEX.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children and adults with CF, CRP is increased at the initiation of IV antibiotic therapy for PEX and declines with treatment. The response is more pronounced in highly symptomatic adults with advanced lung disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27487","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T08:42:53Z","timestamp":1737448973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["C\u2010Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary Exacerbations"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-9210","authenticated-orcid":false,"given":"Jonathan B.","family":"Zuckerman","sequence":"first","affiliation":[{"name":"Maine Medical Center Division of Pulmonary and Critical Care Portland Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra C.","family":"Hinton","sequence":"additional","affiliation":[{"name":"Center for Outcomes and Research Evaluation, Maine Medical Center Portland Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-4918","authenticated-orcid":false,"given":"Thomas","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology University of Vermont Medical Center Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte C.","family":"Teneback","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care University of Vermont Medical Center Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-8149","authenticated-orcid":false,"given":"Shijing","family":"Jia","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Mermis","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care University of Kansas Medical Center Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Polineni","sequence":"additional","affiliation":[{"name":"Division of Allergy and Pulmonary Medicine Washington University St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Dasenbrook","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-8183","authenticated-orcid":false,"given":"Hossein","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, Division of Pediatric Pulmonology New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"DiMango","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, Division of Pulmonary and Critical Care New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Dezube","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medical Center, Division of Pulmonary and Critical Care Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0025-2422","authenticated-orcid":false,"given":"Natalie E.","family":"West","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medical Center, Division of Pulmonary and Critical Care Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-9337","authenticated-orcid":false,"given":"Edith T.","family":"Zemanick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus and Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4124-316X","authenticated-orcid":false,"given":"Z. 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