{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:00:14Z","timestamp":1785297614994,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>New CFTR Modulator triple therapy Elexacaftor\u2010Ivacaftor\u2010Tezacaftor (ETI) prove efficacy in pulmonary outcomes. However, its impact on nasal sinus symptoms in children has not been specifically studied. The aim of this study is to evaluate the impact of this therapy on nasal sinus symptomatology in children aged 6\u201312 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, single\u2010center cohort study was conducted over a 12\u2010month follow\u2010up period in children aged 6\u201312 years at the initiation of ETI therapy. The primary outcome was evolution of the SN\u20105 score, a validated pediatric questionnaire measuring quality of life related to nasal sinus symptoms. A decrease of 0.5 points is considered clinically significant. Secondary outcomes included changes in clinical examination findings (obstructive turbinate hypertrophy, polyps, presence of pus in the middle meatus, and externalized mucocele), quality of life measured by the Visual Analog Scale (VAS), and number of antibiotic courses during the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six patients were included between March and September 2023, with no lost to follow\u2010up. The initial mean SN\u20105 score was 2.88 (95% CI {1.91; 3.85}). After 1 year, the mean SN\u20105 score was significantly lower (1.41, 95% CI {1.00; 1.88}, Delta = 1.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The VAS related to symptoms also improved (Delta = 1.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and the number of antibiotic courses decreased (25 vs. 69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A trend toward improvement in clinical examination parameters was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ETI therapy appears to significantly improve nasal sinus symptoms in children aged 6\u201312 years, as evidenced by improved quality\u2010of\u2010life scales and reduced antibiotic use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27493","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:31:54Z","timestamp":1737970314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Elexacaftor\u2010Tezacaftor\u2010Ivacaftor on Nasal and Sinus Symptoms in Children With Cystic Fibrosis"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0210-6983","authenticated-orcid":false,"given":"Guillaume","family":"Petit","sequence":"first","affiliation":[{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon 59 Boulevard Pinel Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Coudert","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon 59 Boulevard Pinel Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Hermann","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon 59 Boulevard Pinel Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Truy","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon 59 Boulevard Pinel Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2205-9655","authenticated-orcid":false,"given":"Maxime","family":"Bonjour","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon 59 Boulevard Pinel Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9192-8335","authenticated-orcid":false,"given":"Philippe","family":"Reix","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon 59 Boulevard Pinel Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ayari","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon 59 Boulevard Pinel Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60327-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2021.1912732"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01662"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16030410"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807120"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2021.0589"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.05.030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202209-763OC"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23439"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30937"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14122"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202101-057OC"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235638"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2022.110421"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.41"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110706"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800760370873"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.0979"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06875-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.08.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23036"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27125"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/21.089"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.06.010"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100665"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32597-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22953"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25669"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211046719"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199409000-00006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23400"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(13)00150-1"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22332"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00787-24"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.27493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:28:59Z","timestamp":1771428539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ppul.27493"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27493","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27493"}}