{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T23:05:21Z","timestamp":1773702321021,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Non\u2010invasive monitoring techniques have been used more commonly in neonatal clinical practice. The aim of this study was to evaluate the role of lung near\u2010infrared spectroscopy (NIRS) for determination of the severity of Respiratory Distress Syndrome (RDS) and the requirement of surfactant therapy in preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 60 preterm infants with RDS were evaluated in terms of the requirement of surfactant therapy, as surfactant group (SG) or no\u2010surfactant group (CG). Lung NIRS (L\u2010NIRS), including both basal (bL\u2010rSO\n                      <jats:sub>2<\/jats:sub>\n                      ) and apex (aL\u2010rSO\n                      <jats:sub>2<\/jats:sub>\n                      ) lung oxygenation monitoring, was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean bL\u2010rSO\n                      <jats:sub>2<\/jats:sub>\n                      values before surfactant treatment were significantly lower in SG (83\u2009\u00b1\u200910%) than CG (89\u2009\u00b1\u20095%), (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The mean bL\u2010rSO\n                      <jats:sub>2<\/jats:sub>\n                      levels of 85% were found to significantly predict early surfactant requirement with 57% sensitivity and 73% specificity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). The mean bL\u2010rSO\n                      <jats:sub>2<\/jats:sub>\n                      values in the first 4\u2009h were found to be significantly lower in SG who required repeated surfactant (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>L\u2010NIRS\u2009\u2264\u200985% values at NICU admission may be used for determination of surfactant therapy in RDS. In addition, lower mean basal L\u2010NIRS values in the first 4\u2009h of life can also be used to guide repeated doses of surfactant. L\u2010NIRS, either alone or in combination with other methods may be used for management of preterm infants with RDS after confirmation of our results by larger clinical studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71023","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:52:47Z","timestamp":1741632767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel and Promising Method for Prediction of Early Surfactant Requirement in Preterm Infants With Respiratory Distress Syndrome: Pulmonary Near\u2010Infrared Spectroscopy"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-4992","authenticated-orcid":false,"given":"Meliha","family":"Aksoy","sequence":"first","affiliation":[{"name":"Department of Neonatology Health Sciences University, Basaksehir Cam and Sakura City Hospital Ba\u015fak\u015fehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eeyma","family":"Memur","sequence":"additional","affiliation":[{"name":"Department of Neonatology Health Sciences University, Basaksehir Cam and Sakura City Hospital Ba\u015fak\u015fehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-3121","authenticated-orcid":false,"given":"Beril","family":"Yasa","sequence":"additional","affiliation":[{"name":"Department of Neonatology Health Sciences University, Basaksehir Cam and Sakura City Hospital Ba\u015fak\u015fehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merih","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Department of Neonatology Health Sciences University, Basaksehir Cam and Sakura City Hospital Ba\u015fak\u015fehir 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