{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:39:50Z","timestamp":1784720390046,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate lung function patterns measured by oscillometry in children with Down syndrome and determine associations with pulmonary diagnoses that may co\u2010occur with Down syndrome, including evidence of dysphagia, obstructive sleep apnea, tracheomalacia, and congenital heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Patients<\/jats:title><jats:p>Cross\u2010sectional study of children with Down syndrome who were enrolled during 2019\u20132022 at ages 4\u201318 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Children performed oscillometry before and after albuterol administration to obtain respiratory impedance measures of resistance (R) and reactance (X). Aspiration from swallow study, obstructive sleep apnea from polysomnogram, tracheomalacia from flexible bronchoscopy, and congenital heart disease diagnoses were obtained from the electronic medical record.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 50 children with Down syndrome, more negative X (median X5 z\u2010score \u22120.93 [IQR\u2009\u2212\u20092.15, 0.17]) was observed compared to a z\u2010score of zero representing the mean in a pediatric reference population, but R was not increased at any frequency. Neither R nor X were related to tested pulmonary co\u2010occurring diagnoses. Frequency dependence of resistance (R5\u201019) was elevated (median z\u2010score 0.50 [IQR\u2009\u2212\u20090.01, 1.14]), which, in combination with the more negative X, could indicate heterogeneity in peripheral and\/or central airway sizes. After bronchodilator, R5 and AX decreased \u221226% [IQR \u221232%, \u221212%] and \u221243% [IQR \u221258%, \u221228%], respectively, and X5 increased 31% [IQR 12%, 45%], indicating physiological improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our population, a phenotype of lower lung compliance in 50% of children with Down syndrome was not associated with the presence of co\u2010occurring pulmonary diagnoses. More work is needed to understand if this may be related to their diagnosis of DS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.71069","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T20:40:45Z","timestamp":1743367245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oscillometry Phenotypes in Children With Down Syndrome"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-2123","authenticated-orcid":false,"given":"Katharine L.","family":"Hamlington","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine Aurora Colorado USA"},{"name":"Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily H.","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Wolter\u2010Warmerdam","sequence":"additional","affiliation":[{"name":"Anna and John J. Sie Center for Down Syndrome Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica L.","family":"Vielkind","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology University of Rochester Medical Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Brinton","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Keck","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan J.","family":"Bresselsmith","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4665-6630","authenticated-orcid":false,"given":"Jennifer","family":"Maybee","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwen","family":"Jackson","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine Aurora Colorado USA"},{"name":"Anna and John J. Sie Center for Down Syndrome Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-9342","authenticated-orcid":false,"given":"Emily M.","family":"DeBoer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine Aurora Colorado USA"},{"name":"Children's Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Global Down Syndrome Foundation. \u201cFacts and FAQ About Down Syndrome \u201d accessed February 14 2025 https:\/\/www.globaldownsyndrome.org\/about-down-syndrome\/facts-about-down-syndrome\/#Whatis."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08092-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304611"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13214"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00434.2020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2017.07.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00099228231179453"},{"key":"e_1_2_9_9_1","first-page":"513","volume-title":"Archivos de Bronconeumolog\u00eda","author":"Fernandez\u2010Plata R.","year":"2019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdeng.2015.05.004"},{"issue":"61","key":"e_1_2_9_11_1","first-page":"PA2566","article-title":"Pulmonary Functions, Respiratory Muscle Strength and Motor Skills in Children With Down Syndrome: A Comparative Study","volume":"50","author":"\u00dcnal D.","year":"2017","journal-title":"European Respiratory Journal"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01664-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20926"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25984"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00753-2019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2021.04.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2022.107028"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14091819"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(23)00057-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02367.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9725-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.11"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23264"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0284-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26054"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12010148"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-057010"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:29:12Z","timestamp":1745839752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ppul.71069"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71069","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71069"}}