{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:06:18Z","timestamp":1788793578985,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effects of CFTR modulators, particularly elexacaftor\/tezacaftor\/ivacaftor (ETI), on exercise capacity in people with cystic fibrosis (pwCF) remain unclear, with no data available on their impact within the context of an exercise intervention. Therefore, this study aimed to assess the effects of an exercise intervention on exercise capacity in adults with CF, comparing those treated with and without ETI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 56 adult pwCF participated in this quasi\u2010experimental study as part of a rehabilitation program, which included a 3.5\u2010week exercise intervention. The program involved five weekly 45\u2010min sessions, including endurance training on a cycle ergometer. VO<jats:sub>2<\/jats:sub><jats:sub>peak<\/jats:sub> and W<jats:sub>peak<\/jats:sub> were the primary outcomes used to assess changes in exercise capacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intervention significantly increased VO<jats:sub>2<\/jats:sub><jats:sub>peak<\/jats:sub> and W<jats:sub>peak<\/jats:sub> in all pwCF, regardless of ETI use, with similar improvements between groups. PwCF with lower baseline fitness (VO<jats:sub>2<\/jats:sub><jats:sub>peak<\/jats:sub>\u2009\u2264\u200981%pred) showed greater improvements than those with higher fitness (VO<jats:sub>2<\/jats:sub><jats:sub>peak<\/jats:sub>\u2009\u2265\u200982%pred). ppFEV1 remained unchanged, while BMI increased in both groups. Notably, the ETI group spent significantly more time in physical activity (PA) at hard and very hard intensities compared to the non\u2010ETI group. Additionally, a positive correlation was observed between PA intensity and VO<jats:sub>2<\/jats:sub><jats:sub>peak<\/jats:sub> and W<jats:sub>peak<\/jats:sub> in the ETI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Independent of ETI treatment, adult pwCF improve their exercise capacity by participating in a regular exercise program. ETI treatment appears to enhance time spent in higher PA intensities. Despite the effectiveness of CFTR modulators, regular PA and exercise remain essential to maintain and improve exercise capacity in pwCF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.71076","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T16:15:52Z","timestamp":1743610552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of an Exercise Intervention on Exercise Capacity in Adults With Cystic Fibrosis: A Quasi\u2010Experimental Study Comparing Individuals Treated With and Without Elexacaftor\/Tezacaftor\/Ivacaftor"],"prefix":"10.1002","volume":"60","author":[{"given":"Wolfgang","family":"Gruber","sequence":"first","affiliation":[{"name":"Institute of Human Nutrition and Food Science Kiel University Kiel Germany"},{"name":"Pediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Center, Children's Hospital University of Duisburg\u2010Essen Essen 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