{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:33:25Z","timestamp":1779273205142,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As the life expectancy of people with cystic fibrosis (PwCF) increases, understanding long\u2010term complications, including CF\u2010related bone disease (CFBD), is crucial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to longitudinally characterize CFBD and to compare the bone status of pancreatic sufficient (PS) and pancreatic insufficient (PI) PwCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal analysis included PwCF older than 8 years of age who had at least one dual\u2010energy X\u2010ray absorptiometry test between 2008 and 2021. Data were collected on serum parameters of bone metabolism, nutritional history, habitual activity, and fractures in addition to other demographic and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 80 PwCF: 32 (40%) were PS and 48 (60%) PI. Normal dual\u2010energy X\u2010ray absorptiometry results were found in 42 (53%) patients: 16 (50%) in the PS group and 26 (54%) in the PI group (<jats:italic>p<\/jats:italic>\u2009=\u20090.72). Three (9%) of the PS group and seven (15%) of the PI group had at least one <jats:italic>Z<\/jats:italic>\u2010score below \u22122 (<jats:italic>p<\/jats:italic>\u2009=\u20090.49). The longitudinal bone density decline over a mean of 4.8 years was similar in the two groups. In a logistic regression analysis, pancreatic insufficiency was not found to be a risk factor for CFBD. Female sex was the only significant risk factor for a pathological <jats:italic>Z<\/jats:italic>\u2010score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence and severity of CFBD were not found to correlate with pancreatic sufficiency. The similar prevalence of CFBD between patients with PS and PI suggests that screening, and eventually treatment, should be offered to all PwCF, irrespective of pancreatic status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.71078","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:03:25Z","timestamp":1743746605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic Status Is Not a Risk Factor for Cystic Fibrosis\u2010Related Bone Disease"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-0181","authenticated-orcid":false,"given":"Miri","family":"Dotan","sequence":"first","affiliation":[{"name":"Kathy and Lee Graub Cystic Fibrosis Center, Schneider Children's Medical Center of Israel Petach Tikva Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Trau","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-0264","authenticated-orcid":false,"given":"Meir","family":"Mei\u2010Zahav","sequence":"additional","affiliation":[{"name":"Kathy and Lee Graub Cystic Fibrosis Center, Schneider Children's Medical Center of Israel Petach Tikva Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Mussaffi","sequence":"additional","affiliation":[{"name":"Kathy and Lee Graub Cystic Fibrosis Center, Schneider Children's Medical Center of Israel Petach Tikva Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-7777","authenticated-orcid":false,"given":"Yulia","family":"Gendler","sequence":"additional","affiliation":[{"name":"Department of Nursing School of Health Sciences Ariel University Ariel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Blau","sequence":"additional","affiliation":[{"name":"Kathy and Lee Graub Cystic Fibrosis Center, Schneider Children's Medical Center of Israel Petach Tikva Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-0144","authenticated-orcid":false,"given":"Dario","family":"Prais","sequence":"additional","affiliation":[{"name":"Kathy and Lee Graub Cystic Fibrosis Center, Schneider Children's Medical Center of Israel Petach Tikva Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-0636"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-009-9316-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.05.009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04455-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-0093-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24925"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(11)60004-0"},{"issue":"8","key":"e_1_2_11_9_1","first-page":"506","article-title":"Osteoporosis and Gastrointestinal Disease","volume":"6","author":"Katz S.","year":"2010","journal-title":"Gastroenterology & Hepatology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.11.006"},{"issue":"9","key":"e_1_2_11_11_1","first-page":"1725","article-title":"Genetic Expression in Cystic Fibrosis Related Bone Disease. 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