{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:06:41Z","timestamp":1753870001268,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe lung disease such as chronic pulmonary disease (CPD), severe asthma and cystic fibrosis (CF) in children is associated with increased risk of severe COVID\u201019. Information regarding SARS\u2010CoV\u20102 infection, disease severity and outcome of COVID\u201019 is limited in this pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We captured the number of SARS\u2010CoV\u20102 infected children and evaluated COVID\u201019 disease severity in non\u2010immunized children with CPD, asthma, and CF in a cohort at a Danish tertiary center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The number of children with PCR\u2010verified SARS\u2010CoV\u20102 infection in the cohort and in the age\u2010related background population was identified through the Danish Microbiology Database. Clinical data were retrieved from the electronic medical health records and from the Danish Health Authority.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a cohort of 664 children with severe lung disease 594 were either PCR\u2010tested or had an antibody test for SARS\u2010CoV\u20102 infection due to symptoms or exposure and 18 (3%) had verified SARS\u2010CoV\u20102 infection. The total number of verified SARS\u2010CoV\u20102 infection was at that time 34.575(4.342%) thus, not significantly different from the reference population (<jats:italic>p<\/jats:italic>\u2009=\u20090.152). The symptoms ranged from asymptomatic to mild symptoms, and none of the children with severe lung disease required hospitalization due to COVID\u201019. None of the children were treated with antiviral treatment during the acute infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Of the 664 children in the Danish cohort with severe lung disease, none were hospitalized with COVID\u201019. Our findings imply that this particular group of patients do not experience increased risk of severe COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.71094","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T13:07:32Z","timestamp":1744895252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["COVID\u201019 in Children With Severe Lung Disease\u2014A Tertiary Center Cohort Study in Denmark"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8303-9252","authenticated-orcid":false,"given":"Esben","family":"L\u00e6gsgaard","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Health Center of Pediatric Pulmonology and Allergology, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-2869","authenticated-orcid":false,"given":"Signe B\u00f8dker","family":"Thim","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health Center of Pediatric Pulmonology and Allergology, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-4056","authenticated-orcid":false,"given":"Mette","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7010-2350","authenticated-orcid":false,"given":"Sune","family":"Rubak","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health Center of Pediatric Pulmonology and Allergology, Aarhus University Hospital 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2nd Wave of COVID\u201019 Losing Its Force in February (2021) 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