{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T11:01:02Z","timestamp":1771412462953,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n \n Spontaneous breathing trial (SBT) is recommended during weaning from mechanical ventilation (MV), but objective and easy tools lack to identify pediatric weaning failure. We aimed to assess whether changes in estimated arterial CO\u2082 (PaCO\u2082) derived from transcutaneous measurements (P\n TC<\/jats:sub>\n CO\u2082) were associated with pediatric weaning failure.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Children (age 72\u2009h \u201018 years) with MV\u2009>\u200912\u2009h were continuously monitored using a transcutaneous sensor to estimate PaCO\u2082 from skin CO\u2082 tension (P\n TC<\/jats:sub>\n CO\u2082). Values were recorded during SBT (30\u2009min on positive end\u2010expiratory pressure (PEEP) +5 cmH\n 2<\/jats:sub>\n O, with pressure support of +5 cmH\n 2<\/jats:sub>\n O for endotracheal tubes with internal diameter\u2009\u2264\u20093.5\u2009mm), then up to 6\u2009h after extubation. Mean P\n TC<\/jats:sub>\n CO\n 2<\/jats:sub>\n and P\n TC<\/jats:sub>\n CO\n 2<\/jats:sub>\n changes during SBT, and after extubation, were retrospectively collected to evaluate their association with SBT failure and extubation failure (reintubation within 48\u2009h).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighty children (median [IQR] age 1.1 [0.3; 8.7] years) were included, with 89 SBT (14 failures, 75 successes). Sixty\u2010four patients were extubated following their first SBT, with 10 (16%) extubation failures. P\n TC<\/jats:sub>\n CO\n 2<\/jats:sub>\n changes were not associated with SBT and extubation failures. Patients who failed extubation had a higher mean P\n TC<\/jats:sub>\n CO\n 2<\/jats:sub>\n value after extubation as compared to those who were successfully extubated (mean P\n TC<\/jats:sub>\n CO\n 2<\/jats:sub>\n of 51.8 [46.2; 55.4] vs. 42.3 [37.5; 47.2] mmHg,\n p<\/jats:italic>\n \u2009=\u20090.02). The difference between the maximal P\n TC<\/jats:sub>\n CO\n 2<\/jats:sub>\n value within the 2 h following extubation and the value at extubation\u00a0were\u00a0higher in patients who failed extubation (\u0394P\n TC<\/jats:sub>\n CO\n 2<\/jats:sub>\n of 20 [9.1; 26] vs. 6.8 [2.9; 9.7] mmHg,\n p<\/jats:italic>\n \u2009<\u200910\n \u22122<\/jats:sup>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Early post\u2010extubation increase in estimated PaCO\u2082 was associated with extubation failure, whereas P\n TC<\/jats:sub>\n CO\u2082 changes during SBT were not.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ppul.71115","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:20:31Z","timestamp":1746498031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcutaneous Carbon Dioxide Monitoring During Weaning From Mechanical Ventilation in Children: The WeanCO\n 2<\/sub>\n Study"],"prefix":"10.1002","volume":"60","author":[{"given":"Meryl","family":"Vedrenne\u2010Cloquet","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"},{"name":"Pediatric Noninvasive Ventilation and Sleep Unit, EA 7330 VIFASOM AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"},{"name":"University of Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-7080","authenticated-orcid":false,"given":"Charlotte","family":"Collignon","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"De Cacqueray","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Grapin","sequence":"additional","affiliation":[{"name":"Nephrology department AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Oualha","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"},{"name":"University of Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Renolleau","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"},{"name":"University of Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Griffon","sequence":"additional","affiliation":[{"name":"Pediatric Noninvasive Ventilation and Sleep Unit, EA 7330 VIFASOM AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"},{"name":"University of Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4163-5021","authenticated-orcid":false,"given":"Sonia","family":"Khirani","sequence":"additional","affiliation":[{"name":"Pediatric Noninvasive Ventilation and Sleep Unit, EA 7330 VIFASOM AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"},{"name":"University of Paris Cit\u00e9 Paris France"},{"name":"ASV Sant\u00e9 Gennevilliers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6092-2662","authenticated-orcid":false,"given":"Brigitte","family":"Fauroux","sequence":"additional","affiliation":[{"name":"Pediatric Noninvasive Ventilation and Sleep Unit, EA 7330 VIFASOM AP\u2010HP University Hospital Necker\u2010Enfants malades Paris France"},{"name":"University of Paris Cit\u00e9 Paris 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