{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:45:00Z","timestamp":1773089100352,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a paucity of information on the microbiological profile in Indian children with CF. This study aimed to evaluate the microbial profile of airways in Indian children with CF and to generate antibiotic sensitivity patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children \u2264\u200918 years old with newly diagnosed CF (Clinical and two positive sweat chloride tests) were included. The respiratory samples were collected at enrollment, follow\u2010up (FU), and during pulmonary exacerbation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three hundred and thirteen children were enrolled with a median (IQR) age of 2.8 (0.6, 8) years; 197 (62.9%) were boys. 530 microbiological samples were collected during the study period. At enrollment,\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      was the most common organism detected in 63 (36.8%) children, followed by\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (32, 18.7%),\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (23, 13.4%),\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      (12, 7.0%),\n                      <jats:italic>Acinetobacter baumanii<\/jats:italic>\n                      (8, 4.7%), and\n                      <jats:italic>Haemophilus influenzae<\/jats:italic>\n                      (3, 1.7%). During FU,\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      was also the most common organism detected in 56 (26.8%) samples, followed by\n                      <jats:italic>S. aureus<\/jats:italic>\n                      (43, 20.5%). The median age of\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      infection was 1.3 (0.5, 6.4) years, whereas it was 4.3 (1.5, 12.6) years for\n                      <jats:italic>S. aureus<\/jats:italic>\n                      . Chronic\n                      <jats:italic>P. aeruginosa infection<\/jats:italic>\n                      was noted in 21 (6.7%) children, which was significantly associated with increasing age and lower weight. Antibiotic resistance was observed in 1.8%\u201376.6% of samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study explores the first nationwide microbiological profile of the airway in Indian children with CF.\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      was the most common isolated organism at enrollment and during FU. This study provides antibiotic sensitivity patterns to common organisms that will help to promote antibiotic stewardship and formulate policies for children with CF in this region.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71194","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:20:02Z","timestamp":1753183202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microbiological Profile of Airway in Indian Children With Cystic Fibrosis: A Multicenter Prospective Cohort Study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-8097","authenticated-orcid":false,"given":"Prawin","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences (AIIMS) Jodhpur 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