{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:38:03Z","timestamp":1781534283420,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dupilumab improved clinical outcomes in children (aged 6\u201311 years) with moderate\u2010to\u2010severe asthma and type 2 inflammation (baseline blood eosinophil count \u2265\u2009150 cells\/\u03bcL or fractional exhaled nitric oxide [FeNO] \u2265\u200920 ppb) in the phase 3 VOYAGE study (NCT02948959). We evaluated dupilumab plus medium\u2010dose ICS versus placebo plus continued high\u2010dose ICS in children in VOYAGE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children were randomized to dupilumab 100\/200\u2009mg by body weight or placebo every 2 weeks for 52 weeks. Annualized severe exacerbation rates, change from baseline in pre\u2010bronchodilator percent predicted forced expiratory volume in 1 s (ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      ), morning peak expiratory flow (PEF), 7\u2010item Asthma Control Questionnaire\u2010Investigator Administered (ACQ\u20107\u2010IA) score, FeNO, blood eosinophil count, and total IgE at Week 52 were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 184 children were analyzed (dupilumab plus medium\u2010dose ICS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009134; placebo plus high\u2010dose ICS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950). At Week 52, dupilumab plus medium\u2010dose ICS versus placebo plus high\u2010dose ICS significantly reduced exacerbations by 74.3%, and significantly improved ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      , morning PEF, ACQ\u20107\u2010IA score, FeNO, and total IgE. There was no significant difference in blood eosinophil counts between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children with moderate\u2010to\u2010severe asthma and type 2 inflammation, treatment with dupilumab plus medium\u2010dose ICS reduced exacerbations and improved lung function and asthma control compared with placebo plus continued high\u2010dose ICS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71197","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:33:46Z","timestamp":1753785226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dupilumab Plus Medium\u2010Dose Inhaled Corticosteroid (ICS) Improves Outcomes Compared With Placebo Plus Continued High\u2010Dose ICS in Children With Uncontrolled Moderate\u2010to\u2010Severe Type 2 Asthma"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-2704","authenticated-orcid":false,"given":"Leonard B.","family":"Bacharier","sequence":"first","affiliation":[{"name":"Monroe Carell Jr. Children's Hospital at Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge F.","family":"Maspero","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CIDEA Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos G.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Allergy Department, 2nd Pediatric Clinic University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Clinique Sp\u00e9cialis\u00e9e en Allergie de la Capitale Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa W.","family":"Guilbert","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital and University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"Xia","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc. Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Ledanois","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mena","family":"Soliman","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc. Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. (2024) https:\/\/ginasthma.org\/2024-report\/."},{"key":"e_1_2_11_3_1","unstructured":"National Asthma Education and Prevention Program Third Expert Panel on the Diagnosis and Management of Asthma. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Bethesda (MD): National Heart Lung and Blood Institute (US); (2007) https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK7232\/."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1223"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13450"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714257"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710988"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1868CI"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-015-0075-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.11.020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0301-2019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513737"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.10.027"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00780-2015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.04.031"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00826-2023"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323896111"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324022111"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4624"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1298443"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14151"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2106567"},{"key":"e_1_2_11_24_1","unstructured":"Global Initiative for Asthma (GINA). 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