{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:47:34Z","timestamp":1778802454587,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Disorders of gut\u2212brain interaction (DGBI), such as irritable bowel syndrome, occur at a higher prevalence in adults with cystic fibrosis (CF), compared to the general population. DGBI are associated with impaired quality of life and significant health\u2010system costs. This study aimed to assess the proportion of cwCF with DGBI, compared to non\u2010CF controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Validated for the assessment of DGBI, ROME IV surveys were distributed to cwCF and non\u2010CF controls aged 0\u221218 years as part of the Evaluating the Alimentary Tracts in Health and Disease (EARTH) observational study. CF participants were recruited from the Sydney Children's Hospital (SCH) CF outpatient clinic between 2018 and 2022. Non\u2010CF controls were recruited from outpatient clinics, advertisements, and word\u2010of\u2010mouth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four cwCF (female\u2009=\u200922 [50%], median [IQR] age\u2009=\u20097.04 [2.25\u221211.06] years) and 48 non\u2010CF controls (female\u2009=\u200922 [45.83%], median (IQR) age\u2009=\u20098.04 [3.57\u221212.77] years) completed baseline surveys. Symptoms consistent with at least one DGBI were observed more frequently in cwCF compared to non\u2010CF controls (36.36% vs. 10.42%%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Functional abdominal pain was experienced at a higher prevalence in cwCF compared to non\u2010CF controls (13.79% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). No significant differences in the prevalence of other specific disorders were observed between cwCF and non\u2010CF controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared to non\u2010CF, cwCF were significantly more likely to experience functional abdominal pain, and at least one DGBI collectively. Further large\u2010scale studies are needed to validate our findings and ascertain the role of routine screening of DGBI in pediatric CF cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71214","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:18:15Z","timestamp":1753183095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Disorders of Gut\u2212Brain Interaction in a Pediatric Cystic Fibrosis Cohort"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7967-9920","authenticated-orcid":false,"given":"Jemilla Strode","family":"Smith","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Discipline of Paediatrics &amp; Child Health UNSW Medicine &amp; Health Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-9438","authenticated-orcid":false,"given":"Michael J.","family":"Coffey","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Paediatrics &amp; Child Health UNSW Medicine &amp; Health Sydney Australia"},{"name":"Department of Gastroenterology Sydney Children's Hospital Randwick Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Jaffe","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Paediatrics &amp; Child Health UNSW Medicine &amp; Health Sydney Australia"},{"name":"Department of Respiratory Medicine Sydney Children's Hospital Randwick Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Chuang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Paediatrics &amp; Child Health UNSW Medicine &amp; Health Sydney Australia"},{"name":"Department of Respiratory Medicine Sydney Children's Hospital Randwick Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-1009","authenticated-orcid":false,"given":"Bernadette","family":"Prentice","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Paediatrics &amp; Child Health UNSW Medicine &amp; Health Sydney Australia"},{"name":"Department of Respiratory Medicine Sydney Children's Hospital Randwick Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josie","family":"van Dorst","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Paediatrics &amp; Child Health UNSW Medicine &amp; Health Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee Y.","family":"Ooi","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Paediatrics &amp; Child Health UNSW Medicine &amp; Health Sydney Australia"},{"name":"Department of Gastroenterology Sydney Children's Hospital Randwick Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2023-220100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.10.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13061650"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2020.12.021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.08.022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.058"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12070757"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.17200"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619841545"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.03.011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.226"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55028-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2156254"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26913"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0000858788.62220.d3"},{"key":"e_1_2_11_19_1","article-title":"Exploring the Interconnections of Functional Gut Disorders and Inflammatory Bowel Disease: A Narrative Review Article","volume":"16","author":"Huynh D.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20110"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3310\/nihropenres.13384.1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.10.043"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-033916","article-title":"Evaluating the Alimentary and Respiratory Tracts in Health and Disease (EARTH) Research Programme: A Protocol for Prospective, Longitudinal, Controlled, Observational Studies in Children With Chronic Disease at an Australian Tertiary Paediatric Hospital","volume":"10","author":"Michael J. 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