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Important guidelines for newborn screening and care of infants diagnosed with CF transmembrane conductance regulator (CFTR)\u2010Related Metabolic Syndrome\/Cystic Fibrosis Screen Positive Inconclusive Diagnosis (CRMS\/CFSPID) were published alongside related key lessons from individual programs. Work continues to improve growth and nutrition and treat pulmonary exacerbations. New position papers on care delivery and the care team in the post\u2010CFTR modulator era were developed next to continued information related to CFTR modulator use on treatment burden simplification and side effects, such as mental health and use during pregnancy. 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