{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:28:08Z","timestamp":1787243288983,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In children aged 6\u201311 years who have not responded to daily low\u2010dose inhaled corticosteroids, it is recommended to increase ICS to a medium dose plus as\u2010needed SABA reliever, or to change to combination low\u2010dose ICS\u2010LABA plus as\u2010needed SABA relief. Recently, fluticasone propionate and salmeterol (FSC) have been shown to be more effective than fluticasone propionate alone in preventing exacerbations in patients with eosinophilic asthma. This study aims to evaluate the cost\u2010utility of FSC versus medium doses of FP alone in Colombian patients who do not respond to low\u2010dose inhaled corticosteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A probabilistic Markov model was created to estimate the cost and quality\u2010adjusted life\u2010years (QALYs) of patients with severe asthma in Colombia. Cost\u2010effectiveness was evaluated at a willingness\u2010to\u2010pay (WTP) value of US$5180. This analysis used quality\u2010adjusted life years (QALYs) and costs from a third\u2010payer perspective over a 5\u2010year time horizon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FSC incurs a higher cost than FP alone, with a mean incremental cost of USD 273; it provides a marginal improvement in quality\u2010adjusted life years (QALYs) of 0.06, yielding an incremental cost\u2010utility ratio (ICUR) of USD 4806 per QALY gained. These results imply that FSC might be a cost\u2010effective alternative at a willingness\u2010to\u2010pay (WTP) threshold of USD 5180.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study's findings are aligned with previous evidence on the economic value of ICS\/LABA combinations, which found similar cost\u2010effectiveness ratios for ICS\/LABA therapies within accepted thresholds. Our probabilistic perspective supports FSC's potential as a feasible option in clinical practice for achieving better asthma control in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71244","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T08:05:42Z","timestamp":1754985942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cost\u2010Utility of Fluticasone Propionate\/Salmeterol and Fluticasone Propionate Monotherapy in Step\u2010Up Treatment of Childhood Asthma"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-6612","authenticated-orcid":false,"given":"Jefferson Antonio","family":"Buend\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, Grupo de Investigaci\u00f3n en Farmacolog\u00eda y Toxicolog\u00eda Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Buendia S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, Grupo de Investigaci\u00f3n en Farmacolog\u00eda y Toxicolog\u00eda Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S410036"},{"key":"e_1_2_8_3_1","volume-title":"Global Strategy for Asthma Management and Prevention: GINA Main Report 2024","author":"Global Initiative for Asthma (GINA)","year":"2024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S376929"},{"key":"e_1_2_8_5_1","volume-title":"Market Intelligence Report: Combination Inhalers for Asthma, 2018","author":"Patented Medicine Prices Review 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