{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:02:36Z","timestamp":1792404156394,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Spain was among the first countries to implement universal prophylaxis for respiratory syncytial virus (RSV) using nirsevimab, leading to a 60%\u201380% reduction in bronchiolitis hospital admissions. The main objective of this study was to describe the characteristics of infants admitted with bronchiolitis after RSV prophylaxis had been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted in 15 Spanish pediatric emergency departments during the 2023\u20132024 RSV season. We reviewed medical records coded as \u201cacute bronchiolitis\u201d of infants aged less than 12 months who were hospitalized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 947 infants with bronchiolitis were included. Of these, 198 (20.9%) were ineligible for immunization because they were older than 6 months and had no comorbidities. Among the 749 (79.1%) infants who met the criteria for immunization, 377 (50.3%) received nirsevimab, of whom 159 (42.1%) tested positive for RSV, while 372 (49.7%) were not immunized, with 322 (86.5%) testing positive for RSV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among infants who were not immunized, the most common reason for not receiving nirsevimab was family refusal. Among infants with RSV bronchiolitis, there were no significant differences in PICU admission rates or length of stay between those who were immunized and those who were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>During the first nirsevimab campaign, most bronchiolitis admissions involved healthy children over 6 months of age who were not included in the target population, eligible infants who were not immunized, and immunized infants with non\u2010RSV bronchiolitis. Further studies are needed to analyze the characteristics of immunized patients who are admitted with RSV bronchiolitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71249","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T17:10:37Z","timestamp":1755191437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nirsevimab and Acute Bronchiolitis Admissions in Infants Under One Year of Age"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-8832","authenticated-orcid":false,"given":"David","family":"Andina Mart\u00ednez","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Claret Teruel","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Sant Joan de D\u00e9u Barcelona Spain"},{"name":"University of Barcelona Barcelona Spain"},{"name":"Environment Effects on Child\/Adolescent Well\u2010being Institut de Recerca Sant Joan de D\u00e9u (IRSJD) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Gij\u00f3n Mediavilla","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Doce de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Fern\u00e1ndez Mozo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaia","family":"C\u00e1mara Otegui","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Donostia, Biogipuzkoa Health Research Institute San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ba\u00f1os L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Virgen de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Jim\u00e9nez de la Jara","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Ferrero Garc\u00eda\u2010Loygorri","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Gregorio Mara\u00f1\u00f3n Madrid 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Lorenzo","family":"Guerra Diez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Marqu\u00e9s de Valdecilla Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Ranera M\u00e1laga","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Corporacio Sanitaria Parc Tauli Institut d'Investigaci\u00f3 e innovacio Sabadell Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Escalada Pellitero","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario de Canarias Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Barrueco Ramos","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Complexo Hospitalario Universitario de A Coru\u00f1a A 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Recommendations for the Use of Nirsevimab Against Respiratory Syncytial Virus for the 2023\u20102024 Season (2023) accessed October 10 2023 https:\/\/www.sanidad.gob.es\/areas\/promocionPrevencion\/vacunaciones\/comoTrabajamos\/docs\/Nirsevimab.pdf."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7241e1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00215-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.6.2400046"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12040383"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-066584"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23750"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2014.12.012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-016-0130-1"},{"key":"e_1_2_10_21_1","unstructured":"National Institute for Health and Care Excellence: Bronchiolitis in Children. NG9. London: National Institute forHealth and Clinical Excellence (2021).https:\/\/www.nice.org.uk\/guidance\/ng9."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04840-5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2016.10.002"},{"key":"e_1_2_10_24_1","unstructured":"Spanish Ministry of Health. 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