{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:46:16Z","timestamp":1771523176186,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n Cystic fibrosis (CF) is a prevalent disease in children that affects respiratory function. There is some evidence suggesting the benefit of camel milk on respiratory function. The present study was carried out to evaluate the effect of camel milk on the spirometry parameters of children with CF.<\/jats:p>\n <\/jats:sec>\n \n Patients and Method<\/jats:title>\n A randomized double\u2010blind clinical trial was operated between 2021 and 2022. Sixty CF children aged more than 6 years were included. The intervention consisted of 300 milliliters of camel milk or cow milk (as a placebo) daily for 2 months. The spirometry parameters and medications were assessed before and 2 months after intervention.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty patients completed the trial. Patients were similar in baseline characteristics (\n p<\/jats:italic>\n \u2009>\u20090.05). Two months after intervention the percentage change in the forced expiratory volume (FEV1) was 10 (2, 31) and \u22121 (\u221212, 1) in the intervention and control respectively (\n p<\/jats:italic>\n \u2010value\u2009<\u20090.0001). The percentage change in the forced vital capacity (FVC) was 11 (2, 39) and \u22123 (\u221217, 1) in the intervention and control respectively (\n p<\/jats:italic>\n \u2010value\u2009<\u20090.0001). The percentage change in the FEV1\/FVC was \u22122 (\u22128, 00) and 0 (\u22120.5, 5) in the intervention and control respectively (\n p<\/jats:italic>\n value\u2009=\u20090.002). The dose and frequency of medication remained unchanged 2 months after the intervention. No camel milk\u2010related side effect was seen.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our findings strongly support the benefits of camel milk on respiratory function and the improvement of general conditions in CF patients. More studies are needed to confirm the present evidence.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ppul.71298","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:48:20Z","timestamp":1761659300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Camel Milk on the Spirometry Parameters of Children With Cystic Fibrosis: The First Double Blind Randomized Clinical Trial"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-8486","authenticated-orcid":false,"given":"Seyed Javad","family":"Sayedi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toktam","family":"Kheirabadi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Zibaee","sequence":"additional","affiliation":[{"name":"Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO) Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1582-3961","authenticated-orcid":false,"given":"Elham","family":"Bakhtiari","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.917221"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.03.008"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.02.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2021-216849"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9121898"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.42150"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.32553\/ijmbs.v3i2.131"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/602834"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.855342"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(07)72606-1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26110"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.19082\/7423"},{"issue":"1","key":"e_1_2_12_14_1","article-title":"Effect of Camel Milk on Blood Sugar and Lipid Profile of Patients With Type 2 Diabetes: A Pilot Clinical Trial","volume":"13","author":"Ejtahed H. S.","year":"2015","journal-title":"International Journal of Endocrinology and Metabolism"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2019.104568"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2015-10005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.02.057"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-023-05516-x"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:02:04Z","timestamp":1771426924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ppul.71298"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71298","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71298"}}