{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T08:19:40Z","timestamp":1765181980454,"version":"3.46.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma is influenced by genetic and environmental factors, and emerging evidence suggests that the oral microbiome may play a role in its pathogenesis. This study aimed to explore the causal association between oral microbiome abundance and asthma risk using a two\u2010sample Mendelian randomization (MR) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We utilized genome\u2010wide association studies (GWAS) data comprising 56,167 asthma cases and 408,442 controls of European ancestry, alongside 610 individuals from the Danish ADDITION\u2010PRO cohort for oral microbiome analysis. We selected 267 single nucleotide polymorphisms (SNPs) linked to salivary microbiota as instrumental variables (IVs) with an F\u2010statistic\u2009&gt;\u200910. MR analyses were carried out using inverse variance weighted (IVW), MR\u2010Egger, weighted median, and weighted mode methods, complemented by sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings revealed a significant association between specific salivary microbiota and asthma risk. Notably, increased abundance of Genus Rothia was positively associated with asthma risk (IVW: OR\u2009=\u20091.03), while an unspecified Streptococcus species showed a negative correlation (IVW: OR\u2009=\u20090.97). Sensitivity analyses confirmed these results' robustness, with no signs of pleiotropy or significant heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study suggests a causal relationship between specific oral microbiota and asthma risk, emphasizing the oral microbiome's potential significance in asthma pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71301","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T10:51:53Z","timestamp":1758019913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Causal Association Between Oral Microbiome Abundance and Asthma Risk Using Two\u2010Sample Mendelian Randomization"],"prefix":"10.1002","volume":"60","author":[{"given":"Huagui","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical University Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Hainan Affiliated Hospital of Hainan Medical University Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Hainan Affiliated Hospital of Hainan Medical University Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Hainan Affiliated Hospital of Hainan Medical University Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-1877","authenticated-orcid":false,"given":"Xingjun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical University Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02475-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06714"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09941-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-9-24"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00963-6"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"54","article-title":"The Relationship Between Oral Microbiota and Chronic Obstructive Pulmonary Disease","volume":"54","author":"Yang H.\u2010J","year":"2023","journal-title":"Sichuan Da Xue Xue Bao. 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