{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T08:19:40Z","timestamp":1765181980544,"version":"3.46.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are limited data describing hospitalization rates among infants and young children with CF (cwCF). National administrative claims databases can be used to characterize hospitalizations among cwCF which could inform the future impact of novel therapies increasingly being integrated into routine care for cwCF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of the Merative Medicaid Marketscan database from 2010 to 2019 to characterize hospitalizations among cwCF during their first 3 calendar\u2010years of life. Eligible cwCF were identified using International Classification of Diseases 9\/10 codes and had a pharmacy fill for pancreatic enzymes. Hospitalizations were categorized as complicated neonatal, respiratory, gastrointestinal, or other types using Diagnosis Related Groups (DRG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 518 (62.7%) of unique cwCF were hospitalized, amounting to an overall hospitalization rate of 70.9 (95% CI: 67.0\u201375.0) per 100 child\u2010years. In the birth year complicated neonatal DRGs were most common while in the second and third calendar\u2010years respiratory DRGs were most common. In the second calendar\u2010year of life, respiratory syncytial virus (RSV) and influenza were identified in 11.1% and 6.8% of respiratory hospitalizations, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CwCF experienced a large burden of hospitalizations during their first three calendar\u2010years of life. Respiratory DRGs were most common in the second and third calendar\u2010years and included a substantial proportion of RSV\u2010 and influenza\u2010associated hospitalizations. Such data can inform future work assessing the impact of new therapies for CF and RSV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71302","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T15:01:23Z","timestamp":1758207683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hospitalizations in Infants and Young Children With Cystic Fibrosis Enrolled in Medicaid"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-6372","authenticated-orcid":false,"given":"Laurie P.","family":"Murray","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine, Department of Pediatrics Columbia University Irving Medical Center New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Zamani","sequence":"additional","affiliation":[{"name":"Children's Hospital Association Lenexa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-6858","authenticated-orcid":false,"given":"Jonathan D.","family":"Cogen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine, Department of Pediatrics University of Washington Seattle USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Hall","sequence":"additional","affiliation":[{"name":"Children's Hospital Association Lenexa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-8183","authenticated-orcid":false,"given":"Hossein","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine, Department of Pediatrics Columbia University Irving Medical Center New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Saiman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Disease, Department of Pediatrics Columbia University Irving Medical Center New York USA"},{"name":"Department of Infection Prevention and Control NewYork\u2010Presbyterian Hospital New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"volume-title":"Cystic Fibrosis Foundation Patient Registry 2021 Annual Data Report","year":"2022","key":"e_1_2_11_2_1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822e68e6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa752"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110275"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2216480"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-199"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202301-0084OC"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309189"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7309a4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479973119900612"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25535"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22519"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001956"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003173"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.0206"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2189"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2021.12.001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2016.1196140"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.9912100"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.11.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23715"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24377"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70441-X"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2019-0212"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21586"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.09.069"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piad045"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7234a4"},{"key":"e_1_2_11_30_1","unstructured":"AAP Redbook online. AAP Recommendations for the Prevention of RSV Disease in Infants and Children. American Academy of Pediatrics [February 21 2024] https:\/\/publications.aap.org\/redbook\/resources\/25379\/."},{"key":"e_1_2_11_31_1","unstructured":"AAP\u2010Recommendations\u2010for\u2010the\u2010Prevention\u2010of\u2010RSV Accessed December 2024 FluSurv\u2010NET: Influenza Hospitalization Surveillance Network Centers for Disease Control and Prevention https:\/\/gis.cdc.gov\/GRASP\/Fluview\/FluHospRates.html. Accessed June 2024."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T08:14:51Z","timestamp":1765181691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ppul.71302"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71302","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"type":"print","value":"8755-6863"},{"type":"electronic","value":"1099-0496"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71302"}}