{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:00:40Z","timestamp":1771430440426,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014452","name":"College of Medicine, University of Cincinnati","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma phenotype has implications for presentation and treatment selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of patients attending a pediatric pulmonary clinic (2009\u20132015) with EHR data available for phenotyping (allergic, eosinophilic\/non\u2010allergic or non\u2010allergic\/non\u2010eosinophilic). Patients were classified by age. A multinomial regression model examined factors associated with phenotype. A logistic regression model examined factors associated with a change in phenotype (present\/absent).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 2042 patients included. Approximately 44% of participants were allergic, 17% eosinophilic\/non\u2010allergic and 39% non\u2010allergic\/non\u2010eosinophilic. Among children 0\u20134 years, age of asthma onset (aOR 1.42, 95% CI 1.21, 1.65) and mean exacerbations (aOR 1.26 95% CI 1.09, 1.44) were associated with higher odds of an allergic phenotype (vs. non\u2010allergic\/non\u2010eosinophilic). Among those aged 5\u201311 and 12\u201321, male sex and mild obstruction were positively associated, and age was negatively associated, with an allergic phenotype. Moderate\/severe obstruction on spirometry (aOR 6.67, 95% CI 2.00, 22.29) and smoke exposure (aOR 1.77, 95% CI 1.17, 2.67) were also positively associated with an allergic phenotype in patients 12\u201321 years. Factors positively associated with a change in phenotype included index phenotype (eosinophilic\/non\u2010allergic: aOR 5.31, 95% CI 3.46, 8.14) and mean exacerbations (aOR 1.34, 95% CI 1.16, 1.55) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091379). The allergic phenotype was most stable (&gt;\u200995% predicted probability of remaining allergic); an eosinophilic\/non\u2010allergic phenotype had the greatest predicted probability of change (48%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Factors associated with asthma phenotype vary by age. The allergic phenotype was the most stable, while an eosinophilic\/non\u2010allergic phenotype was most prone to change.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71319","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:23:00Z","timestamp":1760556180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asthma Phenotype Progression in Children and Adolescents: A Single Center Experience"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9329-9459","authenticated-orcid":false,"given":"Christine L.","family":"Schuler","sequence":"first","affiliation":[{"name":"Division of Hospital Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio 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