{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:01:02Z","timestamp":1771430462991,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n High\u2010frequency oscillatory ventilation (HFOV) presents challenges for noninvasive CO\n 2<\/jats:sub>\n monitoring due to its rapid oscillations. This study examines the feasibility of instantaneous CO\n 2<\/jats:sub>\n partial pressure (INST CO\n 2<\/jats:sub>\n ) monitoring during HFOV with a capnometer equipped with a mainstream CO\n 2<\/jats:sub>\n sensor.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study included seven neonates receiving HFOV in the neonatal intensive care unit (NICU) at Shizuoka Children's Hospital. INST CO\n 2<\/jats:sub>\n values were recorded over 3\u2010 and 5\u2010min intervals surrounding each blood gas sampling to determine the maximum INST CO\n 2<\/jats:sub>\n value (INST CO\n 2<\/jats:sub>\n MX). The primary outcome was the correlation between INST CO\n 2<\/jats:sub>\n MX and arterial partial pressure of carbon dioxide (PCO\n 2<\/jats:sub>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 216 paired INST CO\n 2<\/jats:sub>\n MX and PCO\n 2<\/jats:sub>\n values were analyzed. The coefficient of determination (\n R<\/jats:italic>\n 2<\/jats:sup>\n ) was 0.571 for INST CO\n 2<\/jats:sub>\n MX (3\u2009min) and 0.579 for INST CO\n 2<\/jats:sub>\n MX (5\u2009min). Univariable and multivariable analyses revealed that a lower fraction of inspired oxygen (FiO\n 2<\/jats:sub>\n ), reduced minute ventilation, and increased postnatal age were associated with improved concordance between INST CO\n 2<\/jats:sub>\n MX and PCO\n 2<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n INST CO\n 2<\/jats:sub>\n MX demonstrated a strong correlation with PCO\n 2<\/jats:sub>\n in neonates undergoing HFOV. This novel, noninvasive monitoring approach may serve as a valuable tool for neonatal respiratory management. Future research is needed to validate these findings in broader patient populations and across various ventilatory settings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ppul.71323","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:01:24Z","timestamp":1760533284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exhaled Carbon Dioxide Monitoring Using Instantaneous CO\n 2<\/sub>\n Mode During High\u2010Frequency Oscillatory Ventilation in Very Low Birth Weight Infants"],"prefix":"10.1002","volume":"60","author":[{"given":"Yusuke","family":"Nakazawa","sequence":"first","affiliation":[{"name":"Nakazawa Kodomo Clinic Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-024X","authenticated-orcid":false,"given":"Kazuto","family":"Ueda","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal\u2010Neonatal Care, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Tanahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyota Memorial Hospital Toyota Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Nakazawa Kodomo Clinic Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-9176","authenticated-orcid":false,"given":"Yoshiaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal\u2010Neonatal Care, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Guideline Alliance (UK). NICE Evidence Reviews Collection. Evidence Reviews for Monitoring: Specialist Neonatal Respiratory Care for Babies Born Preterm: Evidence Review D. (National Institute for Health and Care Excellence (NICE) 2019)."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22267"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.10.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/32065"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04212"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.09.051"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/61.5.628"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-016-0228-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22593"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21558"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24738"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.7_spec_no.743"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:01:29Z","timestamp":1771426889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ppul.71323"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71323","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71323"}}