{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:33:59Z","timestamp":1792499639767,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess lung aeration changes during clinically directed transitions from CPAP to HFNC in preterm infants using Electrical Impedance Tomography (EIT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single\u2010center, Level IV Neonatal Intensive Care Unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Infants born &lt;\u200932 weeks gestational age (GA) undergoing a clinically indicated transition from CPAP to HFNC following \u2265\u20092 weeks of respiratory support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>EIT data were recorded for 30\u201360\u2009min before and after transition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The primary outcome was change in end\u2010expiratory lung impedance (\u0394EELI). Infants were followed for 7 days following transition to assess for transition failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 15 subjects, 4257 total breaths were analyzed. No significant difference in %\u2206EELI was found between HFNC and CPAP (Median \u2206: \u20131.0%; IQR \u20133.6% to 6.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.78). The largest %\u2206EELI decrease (\u20139.8%) occurred in the subject who failed transition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transitioning from CPAP to HFNC did not consistently decrease lung aeration in stable preterm infants. In the infant who failed transition, a distinct respiratory pattern was observed using EIT, characterized by a decrease in EELI and frequent recruitment breaths. These findings suggest better methods are needed to individualize and titrate respiratory support at the bedside for preterm infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71328","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:01:18Z","timestamp":1760533278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating Clinically Directed Continuous Positive Airway Pressure to High Flow Nasal Cannula Transitions in Stable Preterm Infants Using Electrical Impedance Tomography: A Prospective, Observational Study"],"prefix":"10.1002","volume":"60","author":[{"given":"David M.","family":"Rub","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"},{"name":"Division of Neonatology Children\u2032s Hospital of Philadelphia Philadelphia Pennsylvania 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Foglia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"},{"name":"Division of Neonatology Children\u2032s Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard B.","family":"Panitch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"},{"name":"Division of Pulmonary and Sleep Medicine Children\u2032s Hospital of Philadelphia Philadelphia Pennsylvania 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