{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:03:08Z","timestamp":1784602988272,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma is an important global healthcare problem, and severe asthma affects 5%\u20137% of children with asthma. This small percentage results in a heavy burden of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the characteristics of severe asthma patients in Argentina and their evolution over time, and to evaluate the effectiveness of a multidisciplinary team (MDT) approach in the clinical management of these children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, observational, longitudinal study in an Argentinian Pulmonology Service.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010three children aged 5\u201315 years old diagnosed with severe asthma were studied over a period of 6 months; 40\/53 (76%) patients were unable to access therapy (WHO Group 1) and 27\/40 were finally categorized as patients with difficult\u2010to\u2010treat asthma after completing the program. The remaining 13 patients in Group 1 who were non\u2010responders were classified as severe therapy\u2010resistant asthma (STRA). Of the 13 patients who were not initially in Group 1, 8\/13 were responders who no longer had severe asthma and were thus classified as difficult\u2010to\u2010treat asthma and the remaining five had STRA; thus 35\/53 (66%) of the treated patients were no longer classified as severe asthma after completing the program. We identified adverse psychosocial factors identified in 47%. 77% had allergic rhinitis. Most had normal spirometry. Blood eosinophil count was median of 320 cell\/\u00b5L, and median total IgE was 313 UI\/ml. During the program, asthma symptoms, quality of life and asthma exacerbations all improved significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our multidisciplinary approach was associated with better outcomes in most patients with severe asthma. This model could profitably be adopted in other low\u2010resource settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71330","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:22:41Z","timestamp":1762946561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of a Multidisciplinary Program in the Categorization and Management of Children With Severe Asthma"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6385-1158","authenticated-orcid":false,"given":"Alvaro","family":"Teijeiro","sequence":"first","affiliation":[{"name":"Departamento de Neumonologia Hospital Pedi\u00e1trico de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de Neumonologia Hospital Pedi\u00e1trico de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Grenat","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda y Fisiologia Humana, Carrera de Mecidina, Facultad de Ciencias de la Salud Universidad Cat\u00f3lica de C\u00f3rdoba C\u00f3rdoba Argentina"},{"name":"Departamento de Alergia e Immunolog\u00eda Hospital Pedi\u00e1trico de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Bustos","sequence":"additional","affiliation":[{"name":"Laboratorio de Funci\u00f3n Pulmonar Hospital Pedi\u00e1trico de C\u00f3rdoba C\u00f3rdoba Argentina"},{"name":"Escuela de Kinesiolog\u00eda y Fisioterapia, Facultad de Ciencias M\u00e9dicas Universidad Nacional C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benigno","family":"Morales","sequence":"additional","affiliation":[{"name":"Laboratorio de Funci\u00f3n Pulmonar Hospital Pedi\u00e1trico de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Prunier","sequence":"additional","affiliation":[{"name":"Departamento de Salud Mental Pediatric Hospital of C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Departamento de Salud Mental Pediatric Hospital of C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine Royal Brompton Hospital London 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