{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:52:03Z","timestamp":1789555923419,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prognostic value of third trimester main pulmonary artery (MPA) Doppler indices, two dimensional (2D) lung volume, and thoracic circumference (TC) for composite adverse pulmonary outcome (CAPO) in pregnancies complicated by fetal growth restriction (FGR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort, 105 singleton FGR pregnancies (28\u2009+\u20090\u2009\u2212\u200937\u2009+\u20090 weeks) and 108 controls underwent standardized ultrasound at a tertiary center. MPA acceleration time (AT), ejection time (ET), and pulmonary AT to ET (PAT\/ET) ratio were recorded. 2D lung volume and TC were calculated from axial thoracic sections. The CAPO comprised \u2265\u20091 of: 5\u2010min Apgar &lt;\u20097, respiratory distress syndrome (RDS), continuous positive airway pressure (CPAP), mechanical ventilation, or neonatal intensive care unit (NICU) admission for respiratory compromise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, FGR fetuses had smaller lung volume and TC, higher MPA pulsatility\/resistance indices, and lower PAT\/ET. CAPO occurred in 42.9% of FGR versus 10.2% of controls. Optimal cut\u2010offs were AT\u2009&lt;\u200950.5\u2009ms, PAT\/ET\u2009&lt;\u20090.19, and lung volume &lt;\u200918.9\u2009mL. In multivariable analysis, PAT\/ET\u2009&lt;\u20090.19, AT\u2009&lt;\u200950.5\u2009ms, lung volume &lt;\u200918.9\u2009mL and preterm delivery independently predicted CAPO. Combining PAT\/ET and lung volume increased sensitivity to 82% with 72% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reduced lung volume and aberrant MPA Doppler profiles identify growth restricted fetuses at heightened risk of early neonatal respiratory morbidity. Integrating these pulmonary markers into FGR surveillance may enhance antenatal risk assessment, optimize steroid and delivery timing, and improve neonatal respiratory outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71333","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:10:57Z","timestamp":1761203457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary Vascular Doppler and Fetal Lung Biometry as Predictors of Neonatal Respiratory Complications in Early\u2010 and Late\u2010Onset Fetal Growth Restriction"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-2306","authenticated-orcid":false,"given":"Dilara","family":"Duygulu Bulan","sequence":"first","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology Ankara Etlik City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-8841","authenticated-orcid":false,"given":"Ruken","family":"Dayanan","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology Ankara Etlik City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8832-0081","authenticated-orcid":false,"given":"Neval Cayonu","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology Ankara Etlik City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6144-4225","authenticated-orcid":false,"given":"Seda","family":"Kunt","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Ankara Etlik City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-3474","authenticated-orcid":false,"given":"Sevki","family":"Celen","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology Ankara Etlik City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2025.03.051"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2023.05.022"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP276040"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154480"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.128"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1333132"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-023-00780-w"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26020"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12472"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1799"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.70031"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2022.09.002"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-54603-x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015232"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22219"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1413549"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.21608\/mjcu.2021.217391","article-title":"Fetal Pulmonary Artery Doppler as Non Invasive Predictor for Lung Maturity in Diabetic Patients: Does it Help?","volume":"89","author":"Abd Elhady R. 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