{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:43:12Z","timestamp":1769632992873,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze trends in pertussis mortality and hospitalizations in the Brazilian pediatric population from 1996 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This ecological time\u2010trend study used DATASUS data. Trends were analyzed using joinpoint regression to calculate annual percent change (APC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 714 deaths and 31,307 hospitalizations were recorded. Infants under 1 year were the most affected, representing 97.76% of deaths and 87.78% of hospitalizations. Mortality trends showed a nonsignificant decline from 1996 to 2009 (APC: \u22122.4%; CI: \u22127.9% to 3.5%), a peak from 2009 to 2013 (APC: 70.9%; CI: \u22121.7% to 196.9%), and a significant decline from 2013 to 2022 (APC: \u221241.2%; CI: \u221246.8% to \u221234.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Hospitalization rates followed similar trends: a nonsignificant increase from 1998 to 2010 (APC 0.5%; CI: \u22123.9% to 5.2%), a peak from 2010 to 2013 (APC 89.8%; CI: \u221227.2% to 0.17%), and a significant decline from 2013 to 2023 (APC \u221227.6%; CI: \u221232.8% to \u221222.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A peak in pertussis mortality and hospitalizations occurred from 2009\/2010 to 2013, followed by a steady decline from 2013 onward.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71345","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:24:17Z","timestamp":1762946657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trend of Pertussis Mortality and Hospitalizations in Brazilian Children From 1996 to 2023: An Ecological Study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-5267","authenticated-orcid":false,"given":"Gustavo","family":"Ianzer Moraes","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Universidade Federal do Rio Grande \u2010 FURG Rio Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Ramos","family":"Emmendorfer","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancia da Computa\u00e7\u00e3o Universidade Federal de Santa Maria \u2010 UFSM Santa Maria Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Maradona Marques","family":"da Silva de Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade Federal do Rio Grande \u2010 FURG Rio Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-5840","authenticated-orcid":false,"given":"Linje","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade Federal do Rio Grande \u2010 FURG Rio Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"P.CorniaandB. A.Lipsky \u201cPertussis Infection: Epidemiology Microbiology and Pathogenesis \u201d [Internet]. Waltham (MA): UpToDate; 2024 [cited2024Jun 1] https:\/\/www.uptodate.com\/contents\/pertussis-infection-epidemiology-microbiology-and-pathogenesis?search=coqueluche%20&source=search_result&selectedTitle=5~150&usage_type=default&display_rank=5."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2015.03.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.948846"},{"key":"e_1_2_10_5_1","volume-title":"Pertussis in Other Countries [Internet]","author":"Centers for Disease Control and Prevention","year":"2024"},{"key":"e_1_2_10_6_1","unstructured":"Vaccines Today. \u201c1 000% increase in pertussis cases in Europe \u201d [Internet]. Brussels: Vaccines Today;2024[cited 2024 Sep 1] https:\/\/www.vaccinestoday.eu\/stories\/1000-increase-in-pertussis-cases-in-europe\/."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-024-00821-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1827613"},{"key":"e_1_2_10_9_1","volume-title":"Increase of Pertussis Cases in the EU\/EEA [Internet]","author":"European Centre for Disease Prevention and Control","year":"2024"},{"key":"e_1_2_10_10_1","unstructured":"A.Cr\u00edtica.\u201cCom casos na fronteira de MS Sesau acende alerta para circula\u00e7\u00e3o de coqueluche na Capital \u201d [Internet]. Campo Grande (MS): A Cr\u00edtica;2023[cited 2024 Sep 29] https:\/\/www.acritica.net\/editorias\/saude\/com-casos-na-fronteira-sesau-acente-alerta-para-circulacao-de\/682964\/."},{"key":"e_1_2_10_11_1","volume-title":"Calend\u00e1rio Nacional de Vacina\u00e7\u00e3o [Internet]","author":"Minist\u00e9rio da Sa\u00fade (BR)","year":"2024"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.160193"},{"key":"e_1_2_10_13_1","volume-title":"Calend\u00e1rio de vacina\u00e7\u00e3o [Internet]","author":"Minist\u00e9rio da Sa\u00fade (BR)","year":"2024"},{"key":"e_1_2_10_14_1","volume-title":"DATASUS: informa\u00e7\u00f5es de sa\u00fade\u2014TABNET [Internet]","author":"Minist\u00e9rio da Sa\u00fade (BR)","year":"2024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.09.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.07.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","unstructured":"E.Smout D.Mellon andM.Rae \u201cWhooping Cough Rises Sharply in UK and Europe \u201dBMJ[Internet].2024Apr 2 [cited 2024 Apr 12];385(8426):q736 https:\/\/www.bmj.com\/content\/385\/bmj.q736.full.","DOI":"10.1136\/bmj.q736"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:59:43Z","timestamp":1769590783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ppul.71345"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71345","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71345"}}