{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:05:05Z","timestamp":1769634305600,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rational<\/jats:title>\n                    <jats:p>Remote health\u2010monitoring technologies such as cough monitors can track longitudinal changes in health status in children with cystic fibrosis (cwCF). We assessed the feasibility of a bedside cough monitor and hypothesized that cwCF would have a higher baseline cough frequency compared to healthy controls (HC), which would increase during pulmonary exacerbations (PEx).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cough monitors capturing continuous audio data during pre\u2010set sleep times were provided for 3 months. Data were analyzed over 3 s intervals using a proprietary algorithm (CurieAi, Santa Clara, CA) to identify cough events. Multivariable modeling was used to compare baseline cough frequency (coughs per night) between cwCF and HC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 40 children (20 cwCF and 20 HC; median [range] age 11 years [2\u221218]) between February and August 2024. Most participants were White, 3 (7.5%) identified as Hispanic and\/or Latino. CwCF were all treated with elexacaftor\/tezacaftor\/ivacaftor (ETI); baseline median (range) ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      was 107% (86%\u2212124%). Data were captured over 82% of nights in the study period (median of 75.5 nights per participant, range 4\u2212106). CwCF were more likely to cough at least once during the night compared to HC (IRR\u2009=\u20090.279,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and cough at a higher, albeit non\u2010statistically significant rate (IRR\u2009=\u20091.805,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.082). We could not determine whether cough frequency changed during PEx due to limited data collection surrounding reported PEx.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A passive cough monitor detected nighttime cough in cwCF and HC. CwCF with preserved lung function have more nights with cough than HC despite being on elexacator\/tezacaftor\/ivacaftor (ETI).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71351","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T13:01:34Z","timestamp":1763125294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Home Cough Monitoring Reveals Higher Nighttime Cough Burden in Children With Cystic Fibrosis Compared With Healthy Children"],"prefix":"10.1002","volume":"60","author":[{"given":"Lilah D.","family":"Melzer","sequence":"first","affiliation":[{"name":"Department of Pediatrics Barbara Bush Children\u2032s Hospital, MaineHealth Portland Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Vigers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elinor T.","family":"Hanley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-0067","authenticated-orcid":false,"given":"Amanda","family":"Messinger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1588-4852","authenticated-orcid":false,"given":"Jordana E.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-4465","authenticated-orcid":false,"given":"Scott D.","family":"Sagel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-9337","authenticated-orcid":false,"given":"Edith T.","family":"Zemanick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.8120"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2216474"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01609-4"},{"key":"e_1_2_10_5_1","unstructured":"Cystic Fibrosis Foundation Patient Registry. Annual Data Report Bethesda Maryland 2024 Cystic Fibrosis Foundation. 2023."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-054137"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.014548"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000821"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25421"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2020-icc-003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.07.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007311912777"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.12.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10174"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130908801108"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsg044"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.12.050"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.03139"},{"key":"e_1_2_10_22_1","unstructured":"R. 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