{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:12:51Z","timestamp":1787170371301,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extubation in preterm infants is a complex decision, and clinicians need to balance the risk of respiratory failure with the potential benefits of reducing mechanical ventilation. Lung ultrasound Score (LUS) has emerged as a promising tool to assist in this decision\u2010making process. This study aimed to evaluate the predictive value of LUS score for successful extubation in preterm infants born &lt;\u200935 weeks gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>This is a prospective, observational study that was conducted on 77 preterm infants with gestational age &lt;\u200935 weeks who were supported by invasive mechanical ventilation due to respiratory distress syndrome (RDS). LUS was performed within 2\u2009h before extubation and LUS score was calculated, receiver operating characteristic analysis (AUC) was done to get cut\u2010off score, sensitivity, and specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010six babies (85.7%) were successfully extubated (ES) to noninvasive respiratory support while 11 babies (14.2%) failed extubation (EF) within the 72\u2009h period from the onset of extubation. Pre\u2010extubation LUS score was significantly higher (7.0\u2009\u00b1\u20092.75) in EF group compared to neonates in ES group (4.89\u2009\u00b1\u20091.81) with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 (0.028). A cut\u2010off LUS score &gt;\u20096 had a sensitivity 78.5% and a specificity 67.7% (95% confidence interval: 0.67\u20130.89) to predict extubation failure. Positive predictive value (PPV) was 63.3%, and negative predictive value (NPV) was 75%. The gestational age (GA) was 31.51\u2009\u00b1\u20092.9 in (ES) versus 29.90\u2009\u00b1\u20093.2 weeks in (EF) with no significant difference between both groups as well as birth weight (1661\u2009\u00b1\u2009590\u2009g vs. 1411\u2009\u00b1\u200947\u2009g). Male sex represented 66% of the studied cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LUS score offers a modest predictive value for successful extubation in mechanically ventilated preterm infants. However, Its ease of use and real\u2010time assessment make it a valuable addition to the clinical decision\u2010making process in managing these fragile infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71352","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:18:19Z","timestamp":1761203899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lung Ultrasound Score as a Predictor for Extubation Failure in Preterm Infants"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-8119","authenticated-orcid":false,"given":"Wegdan","family":"Mawlana","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King Salman Armed Forces Hospital Section of Neonatology Tabuk Saudi Arabia"},{"name":"Department of Pediatrics and Neonatology Tanta University Hospital Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elhady","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Salman Armed Forces Hospital Section of Neonatology Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attallah","family":"Alhoweiti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Salman Armed Forces Hospital Section of Neonatology Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Najran Military Hospital, Section of Neonatology Najran Saudi 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