{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:00:56Z","timestamp":1771430456165,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to identify predictors of bronchodilator response (BDR) on oscillometry and spirometry for school\u2010age children with bronchopulmonary dysplasia (BPD). We hypothesized that clinical and neonatal characteristics influence BDR. Participants aged 6\u201312 years enrolled in the Air Quality, Environment and Respiratory Outcomes in BPD (AERO\u2010BPD) observational study performed pre\u2010 and post\u2010bronchodilator oscillometry and spirometry. Measures included forced expiratory volume in 1\u2009s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ), forced vital capacity (FVC), FEV\n                    <jats:sub>1<\/jats:sub>\n                    \/FVC, airway resistance at 5 Hertz (Hz, R\n                    <jats:sub>5<\/jats:sub>\n                    ), resistance between 5\u2009Hz and 19\u2009Hz (R\n                    <jats:sub>5\u201019<\/jats:sub>\n                    ), resonant frequency (F\n                    <jats:sub>res<\/jats:sub>\n                    ), reactance at 5\u2009Hz (X\n                    <jats:sub>5<\/jats:sub>\n                    ), and area under the curve between F\n                    <jats:sub>res<\/jats:sub>\n                    and X\n                    <jats:sub>5<\/jats:sub>\n                    (AX). Spirometric BDR was defined as pre\u2010 minus post\u2010bronchodilator measures relative to predicted. Oscillometry BDR was defined by pre\u2010 minus post\u2010bronchodilator relative to pre\u2010bronchodilator. Positive BDR response was defined as change in (\u0394)AX\u2009&lt;\u2009\u221280%, \u0394R\n                    <jats:sub>5<\/jats:sub>\n                    \u2009&lt;\u2009\u221240%, \u0394X\n                    <jats:sub>5<\/jats:sub>\n                    \u2009&gt;\u2009+50%, \u0394FEV\n                    <jats:sub>1<\/jats:sub>\n                    \u2009&gt;\u2009+10% and \u0394FVC\u2009&gt;\u2009+10%. Logistic regression tested predictors of BDR. Among 119 participants who performed paired pre\u2010 and post\u2010bronchodilator oscillometry and spirometry, median pre\u2010bronchodilator z\u2010scores of all measures were normal (within +\/\u22121.64). More participants had BDR on spirometry than oscillometry (33% per FEV\n                    <jats:sub>1<\/jats:sub>\n                    , 10% per FVC, 9% per X\n                    <jats:sub>5<\/jats:sub>\n                    , 7% per R\n                    <jats:sub>5<\/jats:sub>\n                    , and 3% per AX). Inter\u2010device measures overall correlated weakly. Lower pre\u2010bronchodilator FEV\n                    <jats:sub>1<\/jats:sub>\n                    was strongly associated with increased odds of BDR on both devices, while no neonatal variables showed evidence of associations. In school\u2010aged children with BPD, approximately one\u2010third exhibited BDR. Spirometry showed greater rates of BDR than oscillometry. Lower pre\u2010bronchodilator FEV\n                    <jats:sub>1<\/jats:sub>\n                    was linked with higher likelihood of BDR. Neonatal history does not predict BDR.\n                  <\/jats:p>","DOI":"10.1002\/ppul.71359","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:49:43Z","timestamp":1761659383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Bronchodilator Response on Oscillometry and Spirometry in School\u2010Age Children With Bronchopulmonary Dysplasia"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-6189","authenticated-orcid":false,"given":"Julia. X.","family":"Lee","sequence":"first","affiliation":[{"name":"Divison of Pulmonary Medicine Boston Children\u2032s Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-2330","authenticated-orcid":false,"given":"Morgan E.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Biostatistics and Research Design Center Boston Children\u2032s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob Z.","family":"Sun","sequence":"additional","affiliation":[{"name":"Divison of Pulmonary Medicine Boston Children\u2032s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristyn","family":"Beam","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Newborn Medicine Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lystra P.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Divison of Pulmonary Medicine Boston Children\u2032s Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-831X","authenticated-orcid":false,"given":"Suzanne E.","family":"Dahlberg","sequence":"additional","affiliation":[{"name":"Divison of Pulmonary Medicine Boston Children\u2032s Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Biostatistics and Research Design Center Boston Children\u2032s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-4504","authenticated-orcid":false,"given":"Jonathan M.","family":"Gaffin","sequence":"additional","affiliation":[{"name":"Divison of Pulmonary Medicine Boston Children\u2032s Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.11.049"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113548"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23919"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0441-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01720-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.05.066"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1806OC"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201709-756FR"},{"key":"e_1_2_10_11_1","unstructured":"Most Recent National Asthma Data National Data.2023 https:\/\/www.cdc.gov\/asthma\/most_recent_national_asthma_data.htm."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.5111"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(23)00128-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24473"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.08.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/rrn.s96961"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1045-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26632"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21507"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.020514"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.036"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2021-000915"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","unstructured":"A. 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