{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:34:19Z","timestamp":1792499659387,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central Apnoea of prematurity (AoP) is a common complication in preterm infants. AoP impact oxygenation but it is unclear what its effect is on lung volume and ventilation distribution. Electrical Impedance Tomography is a technique able to continuously and bedside monitor lung volume changes in preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a subset of preterm infants of the CRADL project (Continuous Regional Analysis device for neonate Lung) we extracted, using a self\u2010developed automatic detection algorithm and followed by a hand check central AoP, EIT tracings. These EIT tracings were analysed pre\u2010, during and post apnoea for changes in relative end expiratory lung impedance (EELI), tidal volume, breathing rate, minute volume and ventilation distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 15 preterm infants, 203 apnoeas were identified and included into this study. During apnoeas a significant drop (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in relative EELI was seen but this restored to pre\u2010apnoea levels, mediated by an increased median tidal volume (0.43\u2009AU [0.34\u20130.57] to 0.57\u2009AU [0.47\u20130.70],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Ventilation distribution on a regional level (right\u2014left, anterior\u2014posterior or centre of ventilation) showed no changes pre\u2010 and post\u2010 apnoea.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Central AoP results in a significant decrease in EELI but this restores to pre\u2010apnoea levels by compensatory increased tidal volume. No changes in ventilation distribution were detected after an apnoea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71369","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T12:02:42Z","timestamp":1762948962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in Lung Volume and Ventilation During Apnoea of Prematurity Using EIT"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-4952","authenticated-orcid":false,"given":"Martijn","family":"Miedema","sequence":"first","affiliation":[{"name":"Department of Neonatology Amsterdam UMC, University of Amsterdam Amsterdam The Netherlands"},{"name":"Amsterdam Reproductive and Development Research Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Yerworth","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas D.","family":"Waldmann","sequence":"additional","affiliation":[{"name":"SenTec AG Landquart Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9z","family":"Frerichs","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine University Medical Center Schleswig\u2010 Holstein, Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bayford","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences Middlesex University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton H.","family":"Van Kaam","sequence":"additional","affiliation":[{"name":"Department of Neonatology Amsterdam UMC, University of Amsterdam Amsterdam The Netherlands"},{"name":"Amsterdam Reproductive and Development Research Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1981.tb01957.x"},{"key":"e_1_2_10_3_1","first-page":"789","article-title":"Apnea of Prematurity","volume":"19","author":"Miller M. 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