{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:43:01Z","timestamp":1769632981835,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the relationship between adherence to anti\u2010staphylococcal prophylaxis with amoxycillin\u2010clavulanic acid in the first 2 years of life in children with cystic fibrosis (CF) and microbiological outcomes in the first 6 years of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study of adherence to antistaphylococcal prophylaxis in children diagnosed with cystic fibrosis between 2000 and 2014 in Western Australia. Adherence (high defined as \u2265\u200990%, low defined as \u2264\u200970% days covered) was compared to microbial culture results from bronchoalveolar lavage collected during annual disease surveillance. Fisher's exact tests were used to examine the association between adherence and the presence of three major lung pathogens (\n                      <jats:italic>S. aureus<\/jats:italic>\n                      ,\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      , and\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      species) across three age ranges (0\u20132\u2009y.o., 3\u20134\u2009y.o., and 5\u20136\u2009y.o.).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      124 patients were included in the analysis. Adherence rates were high at 93% (median, interquartile range 67.8%\u201399.0%). Over 6 years prevalence of\n                      <jats:italic>S. aureus<\/jats:italic>\n                      ranged from 4% to 12%,\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      ranged from 2% to 10% and\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      ranged from 4% to 20%. There were no statistically significant differences in culture positivity between high and low adherence groups during the study period. Specifically, increased adherence was not associated with significant differences in the culture rates of lung pathogens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In children with CF, adherence to anti\u2010staphylococcal prophylaxis in the first 2 years of life is not associated with a decrease in\n                      <jats:italic>S. aureus<\/jats:italic>\n                      in the lower airways, questioning the value of such prophylaxis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71379","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T12:41:43Z","timestamp":1763124103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adherence to Anti\u2010Staphylococcal Prophylaxis in the First Two Years of Life and Microbiological Outcomes in the First Six Years of Life in Children With Cystic Fibrosis"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3546-8743","authenticated-orcid":false,"given":"Maryanne","family":"Holmes","sequence":"first","affiliation":[{"name":"Child and Adolescent Health Service of Western Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Palladino","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Service of Western Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Yin","family":"(Joseph) Ho","sequence":"additional","affiliation":[{"name":"Wal\u2010yan Respiratory Research CentreThe Kids Research Institute  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8865-090X","authenticated-orcid":false,"given":"Chris J.","family":"Malajczuk","sequence":"additional","affiliation":[{"name":"Wal\u2010yan Respiratory Research CentreThe Kids Research Institute  Australia"},{"name":"UWA Centre for Child Health Research University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliya V.","family":"Karpievitch","sequence":"additional","affiliation":[{"name":"Wal\u2010yan Respiratory Research CentreThe Kids Research Institute  Australia"},{"name":"School of Biomedical Sciences University of Western Australia Perth Australia"},{"name":"School of Population Health Curtin University Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Service of Western Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillipa","family":"Edmiston","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Service of Western Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-8910","authenticated-orcid":false,"given":"Andr\u00e9","family":"Schultz","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Service of Western Nedlands Australia"},{"name":"Wal\u2010yan Respiratory Research CentreThe Kids Research Institute  Australia"},{"name":"UWA Centre for Child Health Research University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"S.Ahern A.Pourghaderi R.Ruseckaite et al. Australian Cystic Fibrosis Data Registry 2023 Annual Report School of Public Health and Preventive Medicine Monash University.2024(Report No 25)."},{"key":"e_1_2_10_3_1","unstructured":"Cystic Fibrosis Foundation 2023 Annual Data Report. Bethesda Maryland.2023."},{"key":"e_1_2_10_4_1","unstructured":"Cystic Fibrosis Trust UK Cystic Fibrosis Registry 2024 Annual Data Report London.2025."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.08.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.12.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1892OC"},{"issue":"9","key":"e_1_2_10_8_1","article-title":"Prophylactic Anti\u2010Staphylococcal Antibiotics for Cystic Fibrosis","volume":"9","author":"Rosenfeld M.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.139493"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201705-376OC"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.121930"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112897"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1585OC"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1919OC"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1230"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23636"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00238-2018"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23307"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.01.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.03.005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1926"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1103"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213233"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2006.03.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)80190-4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S333534"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202406-1128RL"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(99)90270-6"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.01.008"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.2.6.757"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01290"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01540"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2480-0"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0038-7"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2004.09.013"},{"key":"e_1_2_10_36_1","unstructured":"University of Liverpool Clinical Trials Research Centre: A Randomised Registry Trial https:\/\/www.cfstart.org.uk\/]."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:59:10Z","timestamp":1769590750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ppul.71379"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71379","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71379"}}