{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:22:49Z","timestamp":1781205769135,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL160508\u201001A1 [SMT]"],"award-info":[{"award-number":["T32HL160508\u201001A1 [SMT]"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL146369 [JRF]"],"award-info":[{"award-number":["P01 HL146369 [JRF]"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treprostinil for the treatment of bronchopulmonary dysplasia\u2010associated pulmonary hypertension (BPD\u2010PH) has previously been described in small cohort studies, often used later in the course after failure to improve on other therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective\/Methods<\/jats:title>\n                    <jats:p>We retrospectively describe the clinical course and outcomes of 18 infants (gestational age 26.3\u2009\u00b1\u20092.6 weeks) from 2012 to 2025 who received parenteral treprostinil to treat BPD\u2010PH, including changes in echocardiographic and cardiac catheterization parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients had moderate\u2010to\u2010severe BPD and PH, with a mean pulmonary arterial pressure of 45.6\u2009\u00b1\u200912.7\u2009mmHg at cardiac catheterization prior to treprostinil. Treprostinil was initiated at a median postmenstrual age of 53.5 (IQR: 45.7, 62.6) weeks. Echocardiograms after 3 months of treatment showed improvement of PH severity. At repeat catheterization, mean pulmonary arterial pressure (delta \u221216.4\u2009\u00b1\u200912.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and indexed pulmonary vascular resistance (delta \u22124.2\u2009\u00b1\u20093.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) significantly improved. Ten of 18 infants (55.6%) survived to discharge; BNP\u2009\u2265\u200935\u2009pg\/mL prior to treprostinil initiation demonstrates potential utility for mortality prediction with area under the receiver operator characteristic curve 0.87\u2009\u00b1\u20090.10 (95% CI: 0.67\u20131.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study shows a potential benefit of treprostinil use in moderate\u2010to\u2010severe BPD\u2010PH; larger studies are needed to validate our findings and guide decision\u2010making around treprostinil initiation and duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71448","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:12:07Z","timestamp":1768201927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Use of Treprostinil for Bronchopulmonary Dysplasia Associated Pulmonary Hypertension"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-5843","authenticated-orcid":false,"given":"Stephanie M.","family":"Tsoi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medicine University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8431-7130","authenticated-orcid":false,"given":"Claire","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonary Hypertension University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Colglazier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonary Hypertension University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medicine University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Taleb","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of California San Francisco San Francisco California 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