{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:36:35Z","timestamp":1792794995984,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections (LRTIs) in young children. Additionally, RSV is associated with long\u2010term respiratory morbidities. This study evaluates acute and long\u2010term healthcare utilization (HCU) in infants hospitalized with RSV\u2010associated LRTI (RSV\u2010LRTI) compared to non\u2010RSV LRTI (Non\u2010RSV\u2010LRTI) in a nationwide cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective case\u2010control study used data from Clalit Healthcare Services (CHS), Israel's largest healthcare provider. Infants born between 2015 and 2023, admitted before 12 months of age with LRTI during the RSV season, were included. PCR confirmed RSV\u2010LRTI cases, while controls had negative RSV PCR and positive PCR for other respiratory viruses. Acute HCU was assessed within 30 days post\u2010discharge. Long\u2010term respiratory\u2010related HCU was evaluated up to 6 years of age. Statistical analyses included Poisson regression, adjusting for demographic and clinical potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 8626 infants were included, with 4,951 in the RSV\u2010LRTI group and 3675 in the Non\u2010RSV\u2010LRTI group. The adjusted acute HCUs were higher in RSV\u2010LRTI cases with increased systemic steroid use (IRR\u2009=\u20092.25, 95%CI: 1.94\u20132.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and short\u2010acting beta\u2010agonist use (IRR\u2009=\u20093.80, 95%CI: 3.36\u20134.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The adjusted long\u2010term HCU trends persisted, with significantly higher use of respiratory\u2010related medications and pediatric pulmonologist visits (IRR\u2009=\u20091.21, 95%CI: 1.06\u20131.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) in the RSV\u2010LRTI group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This nationwide study highlights the substantial acute and long\u2010term HCU burden associated with RSV\u2010LRTI compared to Non\u2010RSV\u2010LRTI, underscoring the need for effective preventive strategies for all infants, especially in the first months of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71455","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:35:43Z","timestamp":1766993743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Healthcare Utilization in Children Following Hospitalization for RSV\u2010 Versus Non\u2010RSV Related Lower Respiratory Tract Infections: A Nationwide Retrospective Study"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7372-6262","authenticated-orcid":false,"given":"Guy","family":"Hazan","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University Beer\u2010Sheva Israel"},{"name":"Pediatric Pulmonary Unit, Saban's Children Hospital Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Ofri","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University Beer\u2010Sheva Israel"},{"name":"Research and Innovation Center Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lital","family":"Hertz","sequence":"additional","affiliation":[{"name":"Sanofi Israel Ltd, Vaccines Medical Yakum Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-5868","authenticated-orcid":false,"given":"Oliver","family":"Martyn","sequence":"additional","affiliation":[{"name":"Sanofi A\/S, Vaccines Medical Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University Beer\u2010Sheva Israel"},{"name":"Pediatric Infectious Diseases Unit, Saban's Children Hospital Soroka University Medical Center Beer\u2010Sheva 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