{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:59:58Z","timestamp":1773007198343,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Preeclampsia (PE) is characterized by antenatal hypoxia and inflammation, which may impair neonatal respiratory control. However, its association with apnea of prematurity (AOP) in late preterm infants remains unclear. This study aimed to test the hypothesis that maternal PE is an independent risk factor for AOP in late\u202fpreterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was conducted at Yamanashi Central Hospital between January 2017 and June 2025. Singleton pregnancies delivered between 34^\u2009+\u20090 and\u202f36^\u2009+\u20096\u202fweeks of gestation were included. Early\u2010onset PE was defined as diagnosis before 34 weeks of gestation, and late\u2010onset PE as diagnosis at or after 34 weeks. Multivariable logistic regression analyses were performed to evaluate the association between PE and AOP, adjusting for potential confounders. In Model 1, PE was analyzed as a binary variable. In Model 2, subjects were categorized into three groups: early\u2010onset, late\u2010onset, and no PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 470 mother\u2013infant pairs were analyzed. Among them, 23 women experienced early\u2010onset PE, and 34 experienced late\u2010onset PE. The overall incidence of AOP was 27.9% (131\/470). In Model 1, PE was associated with a higher AOP risk (adjusted odds ratio [aOR], 2.44; 95% confidence interval [CI]: 1.21\u20134.90). In Model 2, early\u2010onset PE was significantly associated with AOP (aOR: 3.42; 95% CI: 1.20\u20139.72), whereas late\u2010onset PE was not (aOR: 1.88; 95% CI: 0.75\u20134.73).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PE, particularly early\u2010onset, was significantly associated with AOP. Incorporating maternal PE status into perinatal risk stratification may help identify late preterm infants at elevated AOP risk and guide timely intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71485","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:37:02Z","timestamp":1769755022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preeclampsia and Risk of Apnea of Prematurity in Late Preterm Infants: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3124-1141","authenticated-orcid":false,"given":"Satoshi","family":"Shinohara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genki","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-7765","authenticated-orcid":false,"given":"Nobuyuki","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Department of Neonatology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-5324","authenticated-orcid":false,"given":"Atsushi","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-6724","authenticated-orcid":false,"given":"Atsushi","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Neonatology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-1097","authenticated-orcid":false,"given":"Rei","family":"Sunami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3757"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1409-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13587"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.04.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.6.2818"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084876"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.8841"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097446"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211182"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054065"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2024"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-4047"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2012.01.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1131"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f73f97"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01010-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adnc.2005.02.010"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP284971"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00417-6"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-016-0061-x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2022-007037"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12419"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.12.060"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.09.008"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8100917"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61135-1"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00006"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0497-4"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.107"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.08.048"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a819a1"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004454.pub4"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(96)00236-3"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:51:44Z","timestamp":1772999504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ppul.71485"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71485","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71485"}}