{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:14:30Z","timestamp":1787066070908,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bronchopulmonary dysplasia is one of the most common complications of preterm birth and has lifelong repercussions in respiratory health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine lung function and exercise capacity and assess potential differences in exertional respiratory pattern and ventilatory and gas exchange responses in school\u2010aged children with a history of prematurity and\/or BPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study including children and adolescents born preterm, with and without BPD, and healthy term\u2010born controls without a known history of asthma. Participants performed spirometry and cardiopulmonary exercise testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010two children aged 6\u221218 years (mean: 11.9 years, SD: 3.1) were enrolled and examined in three groups: preterm\u2010born with BPD (gestational age &lt;\u200932 weeks), preterm\u2010born without BPD (GA\u2009&lt;\u200937 weeks), and term\u2010born controls (GA\u2009\u2265\u200937 weeks). FVC, FEV\n                      <jats:sub>1<\/jats:sub>\n                      , FEF\n                      <jats:sub>25%<\/jats:sub>\n                      <jats:sub>\u221275%<\/jats:sub>\n                      , and FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC were normal and comparable among the three groups. V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak% was reduced in the BPD group and was significantly lower than the control group (mean difference: \u201314.4, CI: \u201328 to \u20130.7, adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), but the difference was not significant when adjusting for height. The BPD group had the highest mean VE\/VCO\n                      <jats:sub>2<\/jats:sub>\n                      adjusted for height (32.7), followed by the preterm (30.3) and the control group (29.5), and the difference between the BPD and control group was statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Moreover, BPD status was significantly associated with increased VE\/VCO\n                      <jats:sub>2<\/jats:sub>\n                      (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009+3.2, CI: 1\u20135.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). The rest of the CPET parameters were within normal limits and comparable among groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with BPD have normal lung function but reduced exercise capacity and decreased ventilatory efficiency during exercise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71492","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:44:14Z","timestamp":1770626654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exercise Capacity and Ventilatory Response in Children Who Were Born Preterm, With and Without Bronchopulmonary Dysplasia"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2198-3694","authenticated-orcid":false,"given":"Eleana","family":"Kouroukli","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, 3<sup>rd<\/sup> Department of Paediatrics Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6806-6343","authenticated-orcid":false,"given":"Kosmas","family":"Sarafidis","sequence":"additional","affiliation":[{"name":"1<sup>st<\/sup> Department of Neonatology Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tsanakas","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, 3<sup>rd<\/sup> Department of Paediatrics Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9505-2054","authenticated-orcid":false,"given":"Elpis","family":"Hatziagorou","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, 3<sup>rd<\/sup> Department of Paediatrics Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023-064153"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00788-2019"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202110-2269ST"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00239-2023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00272-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12811"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1075-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30064-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01720-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1523OC"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26867"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201611-912FR"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0101-2018"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-642ST"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0400419"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2191-0518"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198834397.003.0011"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198834397.003.0009"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12101547"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0326"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106102"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23117"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10081427"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2023.105756"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1222731"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.09.014"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207736"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200005000-00016"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jsm.0000180023.44889.dd"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.107474"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00499"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.12.018"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17498"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0163-2024"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:52:28Z","timestamp":1772999548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ppul.71492"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71492","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71492"}}