{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:34:12Z","timestamp":1780407252294,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Short stature has been associated with reduced life expectancy in people with Cystic Fibrosis (pwCF). We aimed to evaluate linear growth and final height in a Dutch cohort of children with CF, diagnosed in early childhood and now aged\u2009\u2265\u200918 years and identify risk factors for impaired linear growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multicenter longitudinal retrospective cohort study was performed in pwCF born between 1997 and 2004, before implementation of newborn screening (NBS). Anthropometric measurements and CF\u2010related risk factors for poor growth (pulmonary infections, malnutrition, CF\u2010Related Diabetes [CFRD], CF\u2010related liver disease [CFLD]) were obtained annually from ages 0.5 to 10 years and biannually from ages 10 to 18. Measurements were converted to Height\u2010For\u2010Age\u2010For\u2010Target\u2010Height (HFA\u2010TH)\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores. Differences in HFA\u2010TH\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores between pwCF and healthy standards, and risk factors associated with linear growth were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 128 pwCF (60 males) were included. Most patients did not receive modulator\u2010therapy during pubertal growth. In boys, mean HFA\u2010TH\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores at age 18 years (HFA\u2010TH\n                      <jats:sub>18<\/jats:sub>\n                      ) were lower in comparison to healthy standards (\u22120.66 [0.96],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In girls at age 18, a normal mean HFA\u2010TH\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score was found (\u22120.18 [0.78]). Development of CFRD and a greater change in BMI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores between 0.5 and 6 years of age (\u0394BMI\n                      <jats:sub>0.5\u20136<\/jats:sub>\n                      ) were associated with lower HFA\u2010TH\n                      <jats:sub>18<\/jats:sub>\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores in boys. In both sexes, pulmonary function and BMI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores were positively associated with linear growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Boys with CF may have impaired final height, especially those with CFRD or a \u0394BMI\n                      <jats:sub>0.5\u20136<\/jats:sub>\n                      . Glucose metabolism and nutritional status should be monitored closely in pwCF, as these factors may contribute to impaired linear growth.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71504","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:46:04Z","timestamp":1771508764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Linear Growth in Children With Cystic Fibrosis in the Netherlands Born Between 1997\u20132004; Results of a Multicenter Cohort Analysis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-3894","authenticated-orcid":false,"given":"Tamer","family":"G.","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology Wilhelmina Children's Hospital, University Medical Center Utrecht the Netherlands"},{"name":"Department of Pediatric Pulmonology Wilhelmina Children's Hospital, University Medical Center Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"van Santen","family":"H. M.","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Wilhelmina Children's Hospital, University Medical Center Utrecht the Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4823-5872","authenticated-orcid":false,"given":"Bannier","family":"M. A. G. E.","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine MosaKids Children's Hospital, Maastricht University Medical Centre+ Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janssens","family":"H. M.","sequence":"additional","affiliation":[{"name":"Department of Pediatrics division of Respiratory Medicine and Allergology, Erasmus University Medical Center\u2010Sophia Children's Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manai","family":"B. H. A. N.","sequence":"additional","affiliation":[{"name":"Department of Pediatrics division of Respiratory Medicine and Allergology, Erasmus University Medical Center\u2010Sophia Children's Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swolfs","family":"R. J. M.","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Wilhelmina Children's Hospital, University Medical Center Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"van der Ent","family":"C. K.","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Wilhelmina Children's Hospital, University Medical Center Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arets H.","family":"G. M.","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Wilhelmina Children's Hospital, University Medical Center Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"van der Kamp","family":"H. 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