{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:34:22Z","timestamp":1782398062868,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with cystic fibrosis (pwCF) and primary ciliary dyskinesia (pwPCD) are particularly vulnerable to the harmful effects of air pollution due to the impairment of mucociliary clearance (MCC). Despite growing evidence supporting the use of indoor air purification in common lung conditions, its role in CF and PCD remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Clean Air for Rare MCC dIsorders (CARMUCI) study is a randomized, double\u2010blind, cross\u2010over, sham\u2010controlled trial aiming to evaluate the impact of indoor air purification on the respiratory health of pwCF and pwPCD (children and adults) in Cyprus. Sixty\u2010two participants will receive two 3\u2010month intervention periods using identical\u2010looking air purifiers: one 3\u2010month period with active filtration via high\u2010efficiency filters and one 3\u2010month period with a sham unit. Primary outcome will be a mean difference of at least 10% change in lung clearance index, and secondary outcomes will include spirometry, pulmonary exacerbations, inflammatory biomarkers, and health\u2010related quality of life. Exposure to indoor particulate matter (PM) will be continuously monitored using device operation logs and wearable activity trackers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By August 2025, 24 pwCF and 26 pwPCD (20 females, age: 31 [16.1] years) have been enrolled. CARMUCI continues enrollment and will start data collection in September 2025. Results are expected to provide novel evidence on the efficacy of air purification in reducing indoor PM exposure and improving respiratory outcomes in people with chronic MCC disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CARMUCI trial first results are expected in late\u20102027 and may inform future clinical guidelines and environmental health strategies for managing rare MCC disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71514","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:40:34Z","timestamp":1770885634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The CARMUCI Study Design: A Double\u2010Blind, Cross\u2010Over Sham\u2010Controlled Trial of Indoor Air Purification in People With Cystic Fibrosis and Primary Ciliary Dyskinesia"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-1367","authenticated-orcid":false,"given":"Maria G.","family":"Kakkoura","sequence":"first","affiliation":[{"name":"Medical School University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2597-8016","authenticated-orcid":false,"given":"Pinelopi","family":"Anagnostopoulou","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-5352","authenticated-orcid":false,"given":"Panayiotis","family":"Kouis","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1480-693X","authenticated-orcid":false,"given":"Antonis","family":"Michanikou","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Bargiotas","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonia","family":"Adamides","sequence":"additional","affiliation":[{"name":"Pulmonology Clinic Nicosia General Hospital Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phivos","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Hospital \u2018Archbishop Makarios III\u2019 Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavroula F.","family":"Louka","sequence":"additional","affiliation":[{"name":"Biobank.cy Center of Excellence in Biobanking and Biomedical Research University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-2441","authenticated-orcid":false,"given":"Marina","family":"Neophytou","sequence":"additional","affiliation":[{"name":"Department of Civil &amp; Environmental Engineering University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios K.","family":"Nikolopoulos","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthi","family":"Skevaki","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universit\u00e4t Marburg, German Center for Lung Research (DZL) Marburg Germany"},{"name":"Centre for Research and Education in Public Health (CEPHRE), Academy of Athens Athina Greece"},{"name":"Department of Epidemiology, Harvard T.H. 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