{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:39:02Z","timestamp":1790728742457,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To date, there is no data on forced oscillation technique (FOT) as a tool to evaluate elexacaftor\/tezacaftor\/ivacaftor (ETI) modulator in young patients with cystic fibrosis (pwCF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Our study aimed to assess the effect of a 6\u2010month ETI treatment on FOT parameters and compare it to the effect on spirometry and nitrogen multiple\u2010breath washout (N\n                      <jats:sub>2<\/jats:sub>\n                      MBW) parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Forty\u2010nine pwCF (median age 12.39 years, 59.2% male) were assessed with spirometry, N\n                      <jats:sub>2<\/jats:sub>\n                      MBW, and FOT before and 3 and 6 months after receiving ETI. The trends in changes of spirometric and FOT parameters were compared among pwCF of different disease severity and in the three patient groups according to their mutation group, that is, F\/F, F\/non\u2010F, and non\u2010F\/non\u2010F. Panel regression was applied to define the predictors of LCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant change was observed 6 months after receiving ETI in height, weight, BMI, Rs5z\u2010score, Xs5z\u2010score, AXz\u2010score, FEV\n                      <jats:sub>1<\/jats:sub>\n                      z\u2010score, FVCz\u2010score, FEF\n                      <jats:sub>25\u201075<\/jats:sub>\n                      z\u2010score, LCI and sGrs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). FOT followed a similar trend in parameters' change with spirometry and N\n                      <jats:sub>2<\/jats:sub>\n                      MBW three and 6 months after ETI among different severity groups based on LCI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Genotype group was found to have a minor role in ETI efficacy; a significant improvement was found in the non\u2010F\/non\u2010F group in all pulmonary tests (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our preliminary data suggest that oscillometry parameters showed a significant improvement after ETI treatment among all genotype groups. More data are required to assess whether and which FOT parameters could be used as surrogates of LCI or spirometry for the long\u2010term follow\u2010up of pwCF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71527","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:36:34Z","timestamp":1771832194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory Oscillometry and Multimodal Lung Function Assessment of Elexacaftor\/Tezacaftor\/Ivacaftor Response in Children and Young Adults With Cystic Fibrosis"],"prefix":"10.1002","volume":"61","author":[{"given":"Christos","family":"Kogias","sequence":"first","affiliation":[{"name":"Aristotle University of Thessaloniki, Paediatric Pulmonology Unit, 3rd Paediatric Clinic, University General Hospital of Thessaloniki \u201cHippokration\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Sopiadou","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki, Paediatric Pulmonology Unit, 3rd Paediatric Clinic, University General Hospital of Thessaloniki \u201cHippokration\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Fouzas","sequence":"additional","affiliation":[{"name":"University of Patras, Paediatric Pulmonology Unit, Paediatric Clinic, University General Hospital of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrina","family":"Vantsi","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki, Paediatric Pulmonology Unit, 3rd Paediatric Clinic, University General Hospital of Thessaloniki \u201cHippokration\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet\u2010Anna","family":"Chrysochoou","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki, Paediatric Pulmonology Unit, 3rd Paediatric Clinic, University General Hospital of Thessaloniki \u201cHippokration\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Desli","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki, Paediatric Pulmonology Unit, 3rd Paediatric Clinic, University General Hospital of Thessaloniki \u201cHippokration\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Galogavrou","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki, Paediatric Pulmonology Unit, 3rd Paediatric Clinic, University General Hospital of Thessaloniki \u201cHippokration\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Gasparis","sequence":"additional","affiliation":[{"name":"Department of Economics University of Macedonia of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elpis","family":"Hatziagorou","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki, Paediatric Pulmonology Unit, 3rd Paediatric Clinic, University General Hospital of Thessaloniki \u201cHippokration\u201d Thessaloniki 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(tofersen). [Reference ID: 5163072]. Biogen MA Inc. 2023. Available at: FDA Labeling Information accessed March 4 2025."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71527","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:19:27Z","timestamp":1773015567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ppul.71527"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71527","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71527"}}