{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:06:52Z","timestamp":1790345212857,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In recent years, it has become evident that there may be a gross underestimation of the true disease burden of cystic fibrosis (CF) in low\u2010and\u2010middle\u2010income countries. Data on incidence of CF in India are sparse, and optimal CF care is impeded by lack of standardized epidemiological data, limited awareness on the disease impact of CF, and inadequate diagnostic and clinical infrastructure to manage CF. Lack of universal neonatal screening, insufficient sweat testing equipment, and expensive genetic testing preclude timely diagnosis and treatment. Restricted access and costs prohibit consistent use of many CF\u2010specific treatments, leading to high morbidity and early mortality. Early diagnosis is crucial and may be achieved by providing CF\u2010specific education to physicians, ancillary staff, medical trainees, and the community, and by initiating neonatal screening. CF clinical diagnostic scores and indigenously developed sweat collection and analysis are inexpensive diagnostic options when c resources are limited. Targeted mutation panels based on regional heterogeneity of\n                    <jats:italic>CFTR<\/jats:italic>\n                    variants need further investigation. Increasing the number of specialized CF centers will improve access to timely care and reduce travel time significantly. Cost\u2010effective clinical protocols following standardized guidelines (with resource\u2010based modifications) for nutritional health, preventive care, and airway clearance through shared care models are invaluable. Ongoing support for the CF registry initiated by the Indian Council of Medical Research is important for epidemiological assessments and policy change, and patient advocacy through organizations such as CF Trust is vital to increase referrals and diagnostic access, subsidize medications, and procure modulator therapies.\n                  <\/jats:p>","DOI":"10.1002\/ppul.71530","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:54:59Z","timestamp":1772996099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenges and Practical Solutions in the Management of Cystic Fibrosis in Resource\u2010Limited Countries: The Indian Experience"],"prefix":"10.1002","volume":"61","author":[{"given":"Grace R.","family":"Paul","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha D.","family":"Varkki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil K.","family":"Kabra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indraprastha Apollo Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20677"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2005.10.002"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-020-01153-4"},{"key":"e_1_2_16_5_1","unstructured":"India Consanguinity (2021) https:\/\/ruralindiaonline.org\/en\/library\/resource\/national-family-health-survey-nfhs-5-2019-21-india\/."},{"issue":"7","key":"e_1_2_16_6_1","first-page":"612","article-title":"Clinical Profile and Frequency of Delta f508 Mutation in Indian Children With Cystic Fibrosis","volume":"40","author":"Kabra S. 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