{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:12:47Z","timestamp":1773018767003,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystic fibrosis\u2010related diabetes (CFRD) is the most common comorbidity in cystic fibrosis (CF). After the introduction of modulator therapy, extended life expectancy and altered nutritional status may have changed the landscape of CFRD. This study aimed to evaluate the current CFRD management in Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a nationwide, cross\u2010sectional study, we included all individuals in Denmark diagnosed with CFRD, defined by insulin use, \u22652 abnormal OGTTs (2\u2010h glucose \u226511.1\u2009mmol\/L), or elevated HbA1c (&gt;48\u2009mmol\/mol). The cohort was identified using the Danish CF Registry, including all CF cases in Denmark. Health records were reviewed to validate diagnoses and extract data on treatment regimens and glycemic control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 151 people with CFRD, with a prevalence of 40% in adults with CF and 1% in adolescents. Among them, 7% used insulin pumps, 41% used basal\u2010bolus treatment, 11% used only basal or mixed insulin, 6% used only bolus insulin, 33% did not use insulin or oral antidiabetics, and 2% used combinations or had missing data on treatment regimen. Median HbA1c was 48\u2009mmol\/mol, with 10% having HbA1c\u2009\u2265\u200970\u2009mmol\/mol. Continuous glucose monitoring (CGM) users (44%) had a median time in range of 70% and median time below range of 1%. No cases of severe hypoglycemia were recorded in the year before data collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the Danish CFRD cohort glycemic control was generally good, although some remained severely dysregulated. While insulin remains the only antidiabetic treatment, the role of oral antidiabetics is likely to expand in the post\u2010modulator era.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71533","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:32:22Z","timestamp":1771831942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Cystic Fibrosis\u2010Related Diabetes in Denmark\u2014A Population\u2010Based, Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0334-5908","authenticated-orcid":false,"given":"Ingrid","family":"Grimsgaard","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben Herborg","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibi Uhre","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-0155","authenticated-orcid":false,"given":"Daniel","family":"Faurholt\u2010Jepsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majbritt","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Cystic Fibrosis Center Aarhus Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Almdal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0586"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06220-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2021.100278"},{"key":"e_1_2_10_6_1","unstructured":"Cystic Fibrosis Foundation. 2023 Patient Registry: Annual Data Report 2024 www.cff.org\/sites\/default\/files\/2024-09\/2023-Patient-Registry-Annual-Data-Report.pdf."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1768"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2023.02.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13375"},{"key":"e_1_2_10_10_1","unstructured":"Cystic Fibrosis Trust. UK Cystic Fibrosis Registry\u20142023 Annual Data Report 2024 www.cysticfibrosis.org.uk\/sites\/default\/files\/2024-11\/CFT_2023_Annual_Data_Report_Oct2024%201.pdf."},{"key":"e_1_2_10_11_1","unstructured":"A.Zolin A.Adamoli E.Bakkeheim andJ.vanRens ECFSPR Annual Data Report 2022 2024 www.ecfs.eu\/sites\/default\/files\/Annual%20Report_2022_ECFSPR_20240603.pdf."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41697"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2021.100276"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.10.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2024.09.001"},{"key":"e_1_2_10_17_1","unstructured":"Rkkp 0 Dansk Diabetes Database (DDiD) Datakvalitetsrapport \u00c5rlige opg\u00f8relser 2023 2024 www.sundk.dk\/media\/qytheabl\/dansk-diabetes-database-aarsrapport-2024-offentliggjort-version-20250627.pdf."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0585"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2007.07.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143011"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:18:22Z","timestamp":1773015502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ppul.71533"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71533","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71533"}}