{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:23:37Z","timestamp":1794047017044,"version":"4.8.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystic fibrosis (CF) is a genetic disease that affects individuals across the globe, yet people with CF (pwCF) in low\u2010 and middle\u2010income countries (LMICs) have historically been under\u2010represented in research due to diagnostic barriers, limited resources, and lack of registry infrastructure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic created an urgent need for real\u2010time, standardized data on SARS\u2010CoV\u20102 infection in pwCF. The aim of this work was to determine the impact of infection on the CF community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Leveraging existing international relationships and national registries, CF leaders rapidly mobilized a global collaboration spanning 47 countries, integrating both high\u2010income countries (HICs) and LMICs. The global CF community developed standardized data definitions and offered multiple collection platforms, including registry extractions, REDCap databases, and Excel\u2010based forms, minimizing technical requirements and allowing centers without registries to contribute. Data were collated and analyzed to quantify the impact of SARS\u2010CoV\u20102 infection on lung function as well as to identify those at risk for hospitalization and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Through this international effort, data were collected on over 7000 pwCF diagnosed with COVID\u201019 across 47 countries, and 6500 were included in the analysis, of which 515 cases were from an LMIC. Most pwCF who contracted COVID\u201019 experienced mild or moderate illness. Severe outcomes, including hospitalization and mortality, did occur but were generally confined to individuals with advanced lung disease, those who had received lung transplants, or those with other high\u2010risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The global CF COVID\u201019 initiative demonstrated that flexible, low\u2010cost tools, capacity building, and intentional engagement of LMIC partners can reduce barriers to participation. Lessons learned, particularly around equity, sustainability, and harmonization, are directly applicable to future global CF research. Building on this model, the newly formalized Global CF Collaboration: Data &amp; Research aims to strengthen LMIC partnerships, expand registry capacity, and ensure no region is left behind in advancing CF care and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71567","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:02:49Z","timestamp":1773824569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Collaboration in Cystic Fibrosis: Lessons From the COVID\u201019 Pandemic for Low\u2010 and Middle\u2010Income Countries"],"prefix":"10.1002","volume":"61","author":[{"given":"Stephanie Y.","family":"Cheng","sequence":"first","affiliation":[{"name":"Cystic Fibrosis Canada Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-6137","authenticated-orcid":false,"given":"Marco","family":"Zampoli","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Elbert","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egil","family":"Bakkeheim","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine, National Resource Centre for Cystic Fibrosis Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobh\u00e1n B.","family":"Carr","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital, Part of Guy's and St Thomas' NHS Trust and Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Charman","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"St. Michael's Hospital Toronto Ontario Canada"},{"name":"Univeristy of Toronto Toronto Ontario 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